Blood flow and oxygenation status of human tumors: Clinical investigations

Horst J. Feldmann, Michael Molls, Peter Vaupel

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Purpose: There is a large body of evidence suggesting that blood flow and oxygenation of human tumors are important research topics which may explain, in particular, resistance to radiation and to many antineoplastic drugs, which can limit the curability of solid tumors by radiotherapy and chemotherapy. Materials and Methods: This manuscript reviews the clinical investigations which have been performed regarding blood flow and oxygenation status of human tumors in radiation oncology. Results: The possible uses and limitations of the prognostic significance and the changes under therapy measuring blood flow and oxygenation in human tumors were discussed. In addition, several approaches were summarized, which can improve the microvascular O2 availability and perfusion-limited O2 delivery. Conclusion: The clinical data concerning the prognostic significance of blood flow, vascular function and oxygenation of human tumors are relevant for patient selection in clinical oncology. Strategies to improve traditional cancer therapy by modulation of the oxygenation status remain quite promising but more critical research and sophisticated clinical studies are necessary before its true potential is known.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalStrahlentherapie und Onkologie
Issue number1
StatePublished - Jan 1999


  • Blood perfusion
  • Modulation of tumor oxygenation
  • Oxygenation of human tumors
  • Prognostic significance


Dive into the research topics of 'Blood flow and oxygenation status of human tumors: Clinical investigations'. Together they form a unique fingerprint.

Cite this