Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garima Garg; Andreas Muschaweckh; Helena Moreno; Ajithkumar Vasanthakumar; Stefan Floess; Gildas Lepennetier; Rupert Oellinger; Yifan Zhan; Tommy Regen; Michael Hiltensperger; Christian Peter; Lilian Aly; Benjamin Knier; Lakshmi Reddy Palam; Reuben Kapur; Mark H. Kaplan; Ari Waisman; Roland Rad; Gunnar Schotta; Jochen Huehn; Axel Kallies; Thomas Korn

doi:10.1016/j.celrep.2019.01.070

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garima Garg
, Andreas Muschaweckh
, Helena Moreno
, Ajithkumar Vasanthakumar
, Stefan Floess
, Gildas Lepennetier
, Rupert Oellinger
, Yifan Zhan
, Tommy Regen
, Michael Hiltensperger
, Christian Peter
, Lilian Aly
, Benjamin Knier
, Lakshmi Reddy Palam
, Reuben Kapur
, Mark H. Kaplan
, Ari Waisman
, Roland Rad
, Gunnar Schotta
, Jochen Huehn

Axel Kallies, Thomas Korn

Technical University of Munich
University of Munich
University of Melbourne
and University of Melbourne Department of Medical Biology and School of Mathematics and Statistics
Helmholtz Centre for Infection Research (HZI)
University Medical Center
Munich Cluster for Systems Neurology (SyNergy)
Indiana University School of Medicine

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

An inflammatory environment threatens the stability of Foxp3 ⁺ Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.

Original language	English
Pages (from-to)	1854-1868.e5
Journal	Cell Reports
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2019.01.070
State	Published - 12 Feb 2019

Keywords

Blimp1
CNS
CNS2
DNA methyltransferases
Foxp3
Interleukin-6
epigenetic regulation
inflammation
regulatory T cells

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10.1016/j.celrep.2019.01.070

Cite this

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M. H., Waisman, A., Rad, R., Schotta, G., ... Korn, T. (2019). Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell Reports, 26(7), 1854-1868.e5. https://doi.org/10.1016/j.celrep.2019.01.070

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title = "Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation",

abstract = " An inflammatory environment threatens the stability of Foxp3 + Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.",

keywords = "Blimp1, CNS, CNS2, DNA methyltransferases, Foxp3, Interleukin-6, epigenetic regulation, inflammation, regulatory T cells",

author = "Garima Garg and Andreas Muschaweckh and Helena Moreno and Ajithkumar Vasanthakumar and Stefan Floess and Gildas Lepennetier and Rupert Oellinger and Yifan Zhan and Tommy Regen and Michael Hiltensperger and Christian Peter and Lilian Aly and Benjamin Knier and Palam, \{Lakshmi Reddy\} and Reuben Kapur and Kaplan, \{Mark H.\} and Ari Waisman and Roland Rad and Gunnar Schotta and Jochen Huehn and Axel Kallies and Thomas Korn",

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year = "2019",

month = feb,

day = "12",

doi = "10.1016/j.celrep.2019.01.070",

language = "English",

volume = "26",

pages = "1854--1868.e5",

journal = "Cell Reports",

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Garg, G, Muschaweckh, A, Moreno, H, Vasanthakumar, A, Floess, S, Lepennetier, G, Oellinger, R, Zhan, Y, Regen, T, Hiltensperger, M, Peter, C, Aly, L, Knier, B, Palam, LR, Kapur, R, Kaplan, MH, Waisman, A, Rad, R, Schotta, G, Huehn, J, Kallies, A & Korn, T 2019, 'Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation', Cell Reports, vol. 26, no. 7, pp. 1854-1868.e5. https://doi.org/10.1016/j.celrep.2019.01.070

TY - JOUR

T1 - Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

AU - Garg, Garima

AU - Muschaweckh, Andreas

AU - Moreno, Helena

AU - Vasanthakumar, Ajithkumar

AU - Floess, Stefan

AU - Lepennetier, Gildas

AU - Oellinger, Rupert

AU - Zhan, Yifan

AU - Regen, Tommy

AU - Hiltensperger, Michael

AU - Peter, Christian

AU - Aly, Lilian

AU - Knier, Benjamin

AU - Palam, Lakshmi Reddy

AU - Kapur, Reuben

AU - Kaplan, Mark H.

AU - Waisman, Ari

AU - Rad, Roland

AU - Schotta, Gunnar

AU - Huehn, Jochen

AU - Kallies, Axel

AU - Korn, Thomas

PY - 2019/2/12

Y1 - 2019/2/12

N2 - An inflammatory environment threatens the stability of Foxp3 + Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.

AB - An inflammatory environment threatens the stability of Foxp3 + Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.

KW - Blimp1

KW - CNS

KW - CNS2

KW - DNA methyltransferases

KW - Foxp3

KW - Interleukin-6

KW - epigenetic regulation

KW - inflammation

KW - regulatory T cells

UR - https://www.scopus.com/pages/publications/85060759189

U2 - 10.1016/j.celrep.2019.01.070

DO - 10.1016/j.celrep.2019.01.070

M3 - Article

C2 - 30759395

AN - SCOPUS:85060759189

SN - 2639-1856

VL - 26

SP - 1854-1868.e5

JO - Cell Reports

JF - Cell Reports

IS - 7

ER -

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Abstract

Keywords

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