Birth of healthy children after intracytoplasmic sperm injection in two couples with male Kartagener's syndrome

Objective: To describe two cases in which intracytoplasmic sperm injection (ICSI) was successful for patients with infertility due to Kartagener's syndrome. Design: Case report. Setting: Private hospital for gynecology department of reproductive medicine, and university hospital center for andrology. Patient(s): Two couples with primary infertility due to Kartagener's syndrome in the male. Intervention(s): [CS[. Main Outcome Measure(s): Pregnancy and birth after ICSI. Result(s): In both couples, ICSI was successful in the first cycle. The uncomplicated pregnancies resulted in the birth of three healthy children. One female and male/female twins. Conclusion(s): In couples with infertility due to Kartagener's syndrome in the male, ICSI has proved to be a successful therapy resulting in clinically healthy offspring. This knowledge may improve our understanding of the involvement of paternally inherited centrosomes, which nucleate microtubules, in human reproduction.