Birth of healthy children after intracytoplasmic sperm injection in two couples with male Kartagener's syndrome

Annette Von Zumbusch, Klaus Fiedler, Artur Mayerhofer, Berthold Jeßberger, Johannes Ring, Hermann Josef Vogt

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Objective: To describe two cases in which intracytoplasmic sperm injection (ICSI) was successful for patients with infertility due to Kartagener's syndrome. Design: Case report. Setting: Private hospital for gynecology department of reproductive medicine, and university hospital center for andrology. Patient(s): Two couples with primary infertility due to Kartagener's syndrome in the male. Intervention(s): [CS[. Main Outcome Measure(s): Pregnancy and birth after ICSI. Result(s): In both couples, ICSI was successful in the first cycle. The uncomplicated pregnancies resulted in the birth of three healthy children. One female and male/female twins. Conclusion(s): In couples with infertility due to Kartagener's syndrome in the male, ICSI has proved to be a successful therapy resulting in clinically healthy offspring. This knowledge may improve our understanding of the involvement of paternally inherited centrosomes, which nucleate microtubules, in human reproduction.

Original languageEnglish
Pages (from-to)643-646
Number of pages4
JournalFertility and Sterility
Volume70
Issue number4
DOIs
StatePublished - Oct 1998

Keywords

  • Centriole
  • Centrosome
  • ICSI (intracytoplasmic sperm injection)
  • Immotile cilia syndrome
  • Kartagener's syndrome
  • Microtubule

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