Biosynthesis of flavonoids

Werner Heller, Gert Forkmann

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

25 Scopus citations


A rapid and substantial progress to a broad understanding of flavonoid biosynthesis marked the previous reviews of this series of books (Hahlbrock and Grisebach, 1975; Ebel and Hahlbrock, 1982; Heller and Forkmann, 1988), and several other reviews have also appeared (Harborne, 1988; Zaprometov, 1989; Stafford, 1990). Advances achieved in the past few years are restricted to specific steps, filling some of the remaining gaps in this metabolic pathway. Among these reactions are the formation of 3-deoxyanthocyanins and 5-deoxyflavonoids, and the synthesis of the structurally derived pterocarpans, which represent the most prominent group of flavonoid phytoalexins. Among the flavonoid modifications, enzymatic formation of flavonoid sulfate esters and aromatic acylation of anthocyanins with hydroxycinnamic acid glucose esters as donors can be mentioned. Yet the key reaction to one of the main flavonoid classes, the anthocyanins, as well as the formation of epicatechin, the proanthocyanidins and some minor flavonoid-related compounds, such as aurones and dihydrochalcones, still remains a matter of debate.

Original languageEnglish
Title of host publicationThe Flavonoids
Subtitle of host publicationAdvances in Research since 1986
PublisherCRC Press
Number of pages38
ISBN (Electronic)9781351410458
ISBN (Print)9780412480706
StatePublished - 1 Jan 2017
Externally publishedYes


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