TY - JOUR
T1 - Biosensors for the Diagnosis of Celiac Disease
T2 - Current Status and Future Perspectives
AU - Scherf, Katharina Anne
AU - Ciccocioppo, Rachele
AU - Pohanka, Miroslav
AU - Rimarova, Kvetoslava
AU - Opatrilova, Radka
AU - Rodrigo, Luis
AU - Kruzliak, Peter
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response toward both dietary antigens, the gluten proteins of wheat, rye, and barley, and autoantigens, the enzyme tissue transglutaminase (TG2). The small intestine is the target organ. Although routine immunochemical protocols for a laboratory diagnosis of CD are available, faster, easier-to-use, and cheaper analytical devices for CD diagnosis are currently unavailable. This review focuses on biosensors, consisting of a physicochemical transducer and a bioreceptor, as promising analytical tools for diagnosis of CD and other diseases. Examples of recently developed biosensors as well as expectations for future lines of research and development in this field are presented.
AB - Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response toward both dietary antigens, the gluten proteins of wheat, rye, and barley, and autoantigens, the enzyme tissue transglutaminase (TG2). The small intestine is the target organ. Although routine immunochemical protocols for a laboratory diagnosis of CD are available, faster, easier-to-use, and cheaper analytical devices for CD diagnosis are currently unavailable. This review focuses on biosensors, consisting of a physicochemical transducer and a bioreceptor, as promising analytical tools for diagnosis of CD and other diseases. Examples of recently developed biosensors as well as expectations for future lines of research and development in this field are presented.
KW - Antibody
KW - Biosensors
KW - Celiac disease
KW - Diagnosis
KW - ELISA
KW - Immunochemistry
UR - http://www.scopus.com/inward/record.url?scp=84964671320&partnerID=8YFLogxK
U2 - 10.1007/s12033-016-9940-3
DO - 10.1007/s12033-016-9940-3
M3 - Review article
C2 - 27130174
AN - SCOPUS:84964671320
SN - 1073-6085
VL - 58
SP - 381
EP - 392
JO - Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology
JF - Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology
IS - 6
ER -