Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Tatiana M. Zimina, Nikita O. Sitkov, Kamil G. Gareev, Viacheslav Fedorov, Denis Grouzdev, Veronika Koziaeva, Huile Gao, Stephanie E. Combs, Maxim Shevtsov

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

Original languageEnglish
Article number789
JournalBiosensors
Volume12
Issue number10
DOIs
StatePublished - Oct 2022
Externally publishedYes

Keywords

  • biogenic magnetic nanoparticles
  • biosensors
  • drug delivery
  • magnetic nanoparticles
  • magnetosomes
  • magnetotactic bacteria
  • oncotheranostics

Fingerprint

Dive into the research topics of 'Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles'. Together they form a unique fingerprint.

Cite this