Bioreactor and scaffold design for the mechanical stimulation of silk based anterior cruciate ligament grafts

M. Hohlrieder, K. Cicha, A. Teuschl, M. Van Griensven, H. Redl, J. Stampfl

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

A bioreactor for the mechanical stimulation of silk based scaffolds has been developed. The bioreactor simulates the natural movement of the anterior cruciate ligament by applying a biaxial movement on the scaffold. The silk scaffolds are prepared in a way that mimicks the mechanical properties (strength, stiffness) of natural anterior cruciate ligaments. The influence of degumming on the mechanical properties of the scaffolds is investigated and first results on cell cultivation experiments with fibroblasts are presented.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationBiomaterials, Cellular and Tissue Engineering, Artificial Organs
PublisherSpringer Verlag
Pages208-210
Number of pages3
Edition10
ISBN (Print)9783642038990
DOIs
StatePublished - 2009
Externally publishedYes
EventWorld Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings
Number10
Volume25
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs
Country/TerritoryGermany
CityMunich
Period7/09/0912/09/09

Keywords

  • Anterior cruciate ligament
  • Bioreactor
  • Mechanical properties
  • Silk scaffold

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