Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron-porphyrin catalysts

Stephan Enthaler, Björn Spilker, Giulia Erre, Kathrin Junge, Man Kin Tse, Matthias Beller

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of α-substituted ketones. Using 2-propanol as hydrogen donor various protected 1,2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h-1 have been achieved.

Original languageEnglish
Pages (from-to)3867-3876
Number of pages10
JournalTetrahedron
Volume64
Issue number17
DOIs
StatePublished - 21 Apr 2008
Externally publishedYes

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