Biocompatibility of photopolymers for additive manufacturing

Stefan Leonhardt; Martin Klare; Maurice Scheer; Theresa Fischer; Burghard Cordes; Markus Eblenkamp

doi:10.1515/cdbme-2016-0028

Biocompatibility of photopolymers for additive manufacturing

Stefan Leonhardt, Martin Klare, Maurice Scheer, Theresa Fischer, Burghard Cordes, Markus Eblenkamp

Engineering and Design

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

To establish photopolymers for the production of class II or class III medical products by additive manufacturing it is essential to know which components of photopolymeric systems, consisting of monomers, photoinitiators and additives, are the determining factors on their biocompatible properties. In this study the leachable substances of a cured photopolymeric system were eluted and identified by HPLC-MS detection. In addition the cured photopolymer was testes for cytotoxicity and genotoxicity according to DIN EN ISO 10993 for long time applications. The results showed that uncured residual monomers are the determining factor on the biocompatible properties of the photopolymeric system. Strategies to reduce these residual monomers in the cured photopolymer are presented.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Current Directions in Biomedical Engineering
Volume	2
Issue number	1
DOIs	https://doi.org/10.1515/cdbme-2016-0028
State	Published - Sep 2016

Keywords

Additive manufacturing
Biocompatibility
Digital light processing
Monomers
Patient individual medical products
Photopolymeric system

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abstract = "To establish photopolymers for the production of class II or class III medical products by additive manufacturing it is essential to know which components of photopolymeric systems, consisting of monomers, photoinitiators and additives, are the determining factors on their biocompatible properties. In this study the leachable substances of a cured photopolymeric system were eluted and identified by HPLC-MS detection. In addition the cured photopolymer was testes for cytotoxicity and genotoxicity according to DIN EN ISO 10993 for long time applications. The results showed that uncured residual monomers are the determining factor on the biocompatible properties of the photopolymeric system. Strategies to reduce these residual monomers in the cured photopolymer are presented.",

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AU - Klare, Martin

AU - Scheer, Maurice

AU - Fischer, Theresa

AU - Cordes, Burghard

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Biocompatibility of photopolymers for additive manufacturing

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