Biochemistry of the non-mevalonate isoprenoid pathway

Tobias Gräwert, Michael Groll, Felix Rohdich, Adelbert Bacher, Wolfgang Eisenreich

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many eubacteria including the major human pathogen, Mycobacterium tuberculosis, in apicomplexan protozoa including the Plasmodium spp. causing malaria, and in the plastids of plants. The metabolic route is absent in humans and is therefore qualified as a promising target for new antiinfective drugs and herbicides. Biochemical and structural knowledge about all enzymes involved in the pathway established the basis for discovery and development of inhibitors by high-throughput screening of compound libraries and/or structure-based rational design.

Original languageEnglish
Pages (from-to)3797-3814
Number of pages18
JournalCellular and Molecular Life Sciences
Volume68
Issue number23
DOIs
StatePublished - Dec 2011

Keywords

  • Deoxyxylulose
  • Dimethylallyl diphosphate
  • Isopentenyl diphosphate
  • Isoprenoid biosynthesis
  • Isp proteins
  • Methyerythritol
  • Mevalonate
  • Terpenes

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