Biochemical activities of extracts from Hypericum perforatum L. / 1st Communication: Inhibition of dopamine-β-hydroxylase

Elisabeth Kleber, Thomas Obry, Susanne Hippeli, Werner Schneider, Erich F. Elstner

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Extracts from the herb 'St John's wort' (Hypericum perforatum L.) are used for the treatment of mental depression, nervousness, sleeplessness and for their wound healing, diuretic and antirheumatic properties. As one biochemical mechanism for depression lack of catecholamine neurotransmitters has been discussed. The results of this investigation show that alcoholic extracts from Hypericum perforatum L. on the basis of total hypericin content inhibit dopamine-β-hydroxylase with an IC50 of 0.1 μmol/l; pure commercial hypericin inhibits with an IC50 of 21 μmol/l. Enzymes involved in the synthesis of dopamine from tyrosine, namely tyrosinase and tyrosine decarboxylase, are not influenced by hypericin at concentrations from 1 up to 10 μmol/l.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume49
Issue number2
DOIs
StatePublished - 1999

Keywords

  • Antidepressants
  • Dopamine-β-hydroxylase
  • Hypericin
  • Hypericum perforatum L. extracts

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