Bioanalytical advances in assays for C-reactive protein

Sandeep Kumar Vashist; A. G. Venkatesh; E. Marion Schneider; Christopher Beaudoin; Peter B. Luppa; John H.T. Luong

doi:10.1016/j.biotechadv.2015.12.010

Bioanalytical advances in assays for C-reactive protein

Sandeep Kumar Vashist
, A. G. Venkatesh
, E. Marion Schneider
, Christopher Beaudoin
, Peter B. Luppa
, John H.T. Luong

Institute of Laboratory Medicine

Technical University of Munich
University of California
University Medical Center Ulm and Center of Excellence 'Metabolic Disorders'
University College Cork

Research output: Contribution to journal › Review article › peer-review

139 Scopus citations

Abstract

This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.

Original language	English
Pages (from-to)	272-290
Number of pages	19
Journal	Biotechnology Advances
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.biotechadv.2015.12.010
State	Published - 1 May 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Assays
Bioanalytical advances
Biosensors
C-reactive protein
Diagnostics

Access to Document

10.1016/j.biotechadv.2015.12.010

Cite this

@article{e4b13afe8a1d4c42b991118c617375b5,

title = "Bioanalytical advances in assays for C-reactive protein",

abstract = "This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.",

keywords = "Assays, Bioanalytical advances, Biosensors, C-reactive protein, Diagnostics",

author = "Vashist, \{Sandeep Kumar\} and Venkatesh, \{A. G.\} and \{Marion Schneider\}, E. and Christopher Beaudoin and Luppa, \{Peter B.\} and Luong, \{John H.T.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.biotechadv.2015.12.010",

language = "English",

volume = "34",

pages = "272--290",

journal = "Biotechnology Advances",

issn = "0734-9750",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Bioanalytical advances in assays for C-reactive protein

AU - Vashist, Sandeep Kumar

AU - Venkatesh, A. G.

AU - Marion Schneider, E.

AU - Beaudoin, Christopher

AU - Luppa, Peter B.

AU - Luong, John H.T.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.

AB - This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.

KW - Assays

KW - Bioanalytical advances

KW - Biosensors

KW - C-reactive protein

KW - Diagnostics

UR - https://www.scopus.com/pages/publications/84952682838

U2 - 10.1016/j.biotechadv.2015.12.010

DO - 10.1016/j.biotechadv.2015.12.010

M3 - Review article

C2 - 26717866

AN - SCOPUS:84952682838

SN - 0734-9750

VL - 34

SP - 272

EP - 290

JO - Biotechnology Advances

JF - Biotechnology Advances

IS - 3

ER -

Bioanalytical advances in assays for C-reactive protein

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this