Bioanalytical advances in assays for C-reactive protein

Sandeep Kumar Vashist; A. G. Venkatesh; E. Marion Schneider; Christopher Beaudoin; Peter B. Luppa; John H.T. Luong

doi:10.1016/j.biotechadv.2015.12.010

Bioanalytical advances in assays for C-reactive protein

Sandeep Kumar Vashist, A. G. Venkatesh, E. Marion Schneider, Christopher Beaudoin, Peter B. Luppa, John H.T. Luong

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Research output: Contribution to journal › Review article › peer-review

120 Scopus citations

Abstract

This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.

Original language	English
Pages (from-to)	272-290
Number of pages	19
Journal	Biotechnology Advances
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.biotechadv.2015.12.010
State	Published - 1 May 2016

Keywords

Assays
Bioanalytical advances
Biosensors
C-reactive protein
Diagnostics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biotechadv.2015.12.010

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title = "Bioanalytical advances in assays for C-reactive protein",

abstract = "This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.",

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AU - Vashist, Sandeep Kumar

AU - Venkatesh, A. G.

AU - Marion Schneider, E.

AU - Beaudoin, Christopher

AU - Luppa, Peter B.

AU - Luong, John H.T.

PY - 2016/5/1

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AB - This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.

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Bioanalytical advances in assays for C-reactive protein

Abstract

Keywords

UN SDGs

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