Abstract
The article discusses interferometric experiments carried out on a number of receptor/ligand ('linker') based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker-linker attraction, and (II) a linker-controlled dewetting transition.
| Original language | English |
|---|---|
| Pages (from-to) | 803-815 |
| Number of pages | 13 |
| Journal | Comptes Rendus de l'Academie des Sciences - Series IV: Physics, Astrophysics |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| State | Published - Aug 2001 |
| Externally published | Yes |
Keywords
- Bioadhésion
- Bioadhesion
- Biophysics
- Biophysique
- Ligand-receptor
- Mouillage
- Phase separation
- Récepteur-ligand
- Séparation de phase
- Wetting