Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site

Séverine Freisz; Kathrin Lang; Ronald Micura; Philippe Dumas; Eric Ennifar

doi:10.1002/anie.200800726

Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site

Séverine Freisz, Kathrin Lang, Ronald Micura, Philippe Dumas, Eric Ennifar

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

(Figure Presented) Targeting HIV RNA: High-resolution X-ray structures of the HIV-1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure-based rational drug design aimed against viral replication.

Original language	English
Pages (from-to)	4110-4113
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	47
Issue number	22
DOIs	https://doi.org/10.1002/anie.200800726
State	Published - 19 May 2008
Externally published	Yes

Keywords

Antibiotics
Drug design
HIV
Molecular recognition
RNA structures

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200800726

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abstract = "(Figure Presented) Targeting HIV RNA: High-resolution X-ray structures of the HIV-1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure-based rational drug design aimed against viral replication.",

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AU - Freisz, Séverine

AU - Lang, Kathrin

AU - Micura, Ronald

AU - Dumas, Philippe

AU - Ennifar, Eric

PY - 2008/5/19

Y1 - 2008/5/19

N2 - (Figure Presented) Targeting HIV RNA: High-resolution X-ray structures of the HIV-1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure-based rational drug design aimed against viral replication.

AB - (Figure Presented) Targeting HIV RNA: High-resolution X-ray structures of the HIV-1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure-based rational drug design aimed against viral replication.

KW - Antibiotics

KW - Drug design

KW - HIV

KW - Molecular recognition

KW - RNA structures

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JF - Angewandte Chemie International Edition in English

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Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site

Abstract

Keywords

UN SDGs

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