#Binding and Uptake of 125Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate

Daniela Selmer; E. F. Elstner; Reingard Senekowitsch-Schmidtke; W. Schneider

doi:10.1515/znc-1997-1-217

#Binding and Uptake of ¹²⁵Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate

Daniela Selmer, E. F. Elstner, Reingard Senekowitsch-Schmidtke, W. Schneider

Life Sciences

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4 Scopus citations

Abstract

Specific and unspecific binding and uptake (internalization) by macrophages of 125iodine-labelled, copper-oxidized human low density lipoprotein is differently influenced by the antioxidants a-tocopherol (a-Toc). probucol (Prob), pyridoxal-5'-phosphate (PP) and the magnesium-pyridoxal-5'-phosphate glutamate complex (MPPG). Binding as well as internalization, mediated by the so-called “scavenger receptor” is lower in the presence of MPPG whereas both specific binding and internalization are enhanced. The comparison of the effects in vitro allows a rating of the potentially antiatherogenic and thus protective effects of the tested substances as follows: MPPG > PP > α-Toc > Prob.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	52
Issue number	1-2
DOIs	https://doi.org/10.1515/znc-1997-1-217
State	Published - Feb 1997

Keywords

Low Density Lipoprotein
Macrophage

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Selmer, D., Elstner, E. F., Senekowitsch-Schmidtke, R., & Schneider, W. (1997). #Binding and Uptake of ¹²⁵Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 52(1-2), 97-104. https://doi.org/10.1515/znc-1997-1-217

Selmer, Daniela ; Elstner, E. F. ; Senekowitsch-Schmidtke, Reingard et al. / #Binding and Uptake of ¹²⁵Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages : Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 1997 ; Vol. 52, No. 1-2. pp. 97-104.

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title = "#Binding and Uptake of 125Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate",

abstract = "Specific and unspecific binding and uptake (internalization) by macrophages of 125iodine-labelled, copper-oxidized human low density lipoprotein is differently influenced by the antioxidants a-tocopherol (a-Toc). probucol (Prob), pyridoxal-5'-phosphate (PP) and the magnesium-pyridoxal-5'-phosphate glutamate complex (MPPG). Binding as well as internalization, mediated by the so-called “scavenger receptor” is lower in the presence of MPPG whereas both specific binding and internalization are enhanced. The comparison of the effects in vitro allows a rating of the potentially antiatherogenic and thus protective effects of the tested substances as follows: MPPG > PP > α-Toc > Prob.",

keywords = "Low Density Lipoprotein, Macrophage",

author = "Daniela Selmer and Elstner, {E. F.} and Reingard Senekowitsch-Schmidtke and W. Schneider",

year = "1997",

month = feb,

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language = "English",

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pages = "97--104",

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Selmer, D, Elstner, EF, Senekowitsch-Schmidtke, R & Schneider, W 1997, '#Binding and Uptake of ¹²⁵Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate', Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 52, no. 1-2, pp. 97-104. https://doi.org/10.1515/znc-1997-1-217

#Binding and Uptake of ¹²⁵Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate. / Selmer, Daniela; Elstner, E. F.; Senekowitsch-Schmidtke, Reingard et al.
In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 52, No. 1-2, 02.1997, p. 97-104.

Research output: Contribution to journal › Article › peer-review

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AB - Specific and unspecific binding and uptake (internalization) by macrophages of 125iodine-labelled, copper-oxidized human low density lipoprotein is differently influenced by the antioxidants a-tocopherol (a-Toc). probucol (Prob), pyridoxal-5'-phosphate (PP) and the magnesium-pyridoxal-5'-phosphate glutamate complex (MPPG). Binding as well as internalization, mediated by the so-called “scavenger receptor” is lower in the presence of MPPG whereas both specific binding and internalization are enhanced. The comparison of the effects in vitro allows a rating of the potentially antiatherogenic and thus protective effects of the tested substances as follows: MPPG > PP > α-Toc > Prob.

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Selmer D, Elstner EF, Senekowitsch-Schmidtke R, Schneider W. #Binding and Uptake of ¹²⁵Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of α-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate. Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 1997 Feb;52(1-2):97-104. doi: 10.1515/znc-1997-1-217