Abstract
Bicyclo[2.1.1]hexanes have become increasingly popular building blocks in medicinal chemistry as bridged scaffolds that provide unexplored chemical space. We herein report a visible light-driven approach to these compounds that relies on an intramolecular crossed [2 + 2] photocycloaddition of styrene derivatives enabled by triplet energy transfer. Bicyclo[2.1.1]hexanes were obtained in good to high yields (19 examples, 61%-quantitative yield) and allowed for further functionalizations by consecutive reactions, thereby opening different pathways to decorate the aliphatic core structure.
| Original language | English |
|---|---|
| Pages (from-to) | 8821-8825 |
| Number of pages | 5 |
| Journal | Organic Letters |
| Volume | 24 |
| Issue number | 48 |
| DOIs | |
| State | Published - 9 Dec 2022 |