BENZENE 2009-Health effects and mechanisms of bone marrow toxicity: Implications for t-AML and the mode of action framework

Michael G. Bird; Helmut Greim; Debra A. Kaden; Jerry M. Rice; Robert Snyder

doi:10.1016/j.cbi.2009.12.001

BENZENE 2009-Health effects and mechanisms of bone marrow toxicity: Implications for t-AML and the mode of action framework

Michael G. Bird, Helmut Greim, Debra A. Kaden, Jerry M. Rice, Robert Snyder

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Abstract

This overview of the Symposium and its organization includes a historical survey of the scientific literature in which the relationship of benzene exposure to the development of aplastic anemia and other bone marrow diseases, including acute myeloid (myelogenous) leukemia, is described. Previous conferences on the health effects of benzene are summarized. The important role of the revised World Health Organization classification of tumors of the hematopoietic and lymphoid tissues in clarifying the specific diseases related to benzene exposure is emphasized.

Original language	English
Pages (from-to)	3-6
Number of pages	4
Journal	Chemico-Biological Interactions
Volume	184
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cbi.2009.12.001
State	Published - Mar 2010

Keywords

Acute myeloid leukemia (AML)
Aplastic anemia
Benzene
Bone marrow
Epidemiology
Mode of action
Therapy-related AML (t-AML)
Toxicology

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10.1016/j.cbi.2009.12.001

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title = "BENZENE 2009-Health effects and mechanisms of bone marrow toxicity: Implications for t-AML and the mode of action framework",

abstract = "This overview of the Symposium and its organization includes a historical survey of the scientific literature in which the relationship of benzene exposure to the development of aplastic anemia and other bone marrow diseases, including acute myeloid (myelogenous) leukemia, is described. Previous conferences on the health effects of benzene are summarized. The important role of the revised World Health Organization classification of tumors of the hematopoietic and lymphoid tissues in clarifying the specific diseases related to benzene exposure is emphasized.",

keywords = "Acute myeloid leukemia (AML), Aplastic anemia, Benzene, Bone marrow, Epidemiology, Mode of action, Therapy-related AML (t-AML), Toxicology",

author = "Bird, {Michael G.} and Helmut Greim and Kaden, {Debra A.} and Rice, {Jerry M.} and Robert Snyder",

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AU - Greim, Helmut

AU - Kaden, Debra A.

AU - Rice, Jerry M.

AU - Snyder, Robert

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KW - Acute myeloid leukemia (AML)

KW - Aplastic anemia

KW - Benzene

KW - Bone marrow

KW - Epidemiology

KW - Mode of action

KW - Therapy-related AML (t-AML)

KW - Toxicology

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BENZENE 2009-Health effects and mechanisms of bone marrow toxicity: Implications for t-AML and the mode of action framework

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Keywords

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