Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases

J. R. Siewert; R. Kestlmeier; R. Busch; K. Böttcher; J. D. Roder; J. Müller; C. Fellbaum; H. Höfler

doi:10.1002/bjs.1800830836

Benefits of D₂ lymph node dissection for patients with gastric cancer and pN₀ and pN₁ lymph node metastases

J. R. Siewert, R. Kestlmeier, R. Busch, K. Böttcher, J. D. Roder, J. Müller, C. Fellbaum, H. Höfler

TUM Emeriti of Excellence

Technical University of Munich

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235 Scopus citations

Abstract

A retrospective immunohistological analysis of 100 patients with pT(1- 3) N₀ and pT(1-3) N₁ gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN₀ cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN₀) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D₂ lymph node dissection in gastrict cancer surgery in patients with lymph node metastasis.

Original language	English
Pages (from-to)	1144-1147
Number of pages	4
Journal	British Journal of Surgery
Volume	83
Issue number	8
DOIs	https://doi.org/10.1002/bjs.1800830836
State	Published - 1996

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title = "Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases",

abstract = "A retrospective immunohistological analysis of 100 patients with pT(1- 3) N0 and pT(1-3) N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastrict cancer surgery in patients with lymph node metastasis.",

author = "Siewert, {J. R.} and R. Kestlmeier and R. Busch and K. B{\"o}ttcher and Roder, {J. D.} and J. M{\"u}ller and C. Fellbaum and H. H{\"o}fler",

year = "1996",

doi = "10.1002/bjs.1800830836",

language = "English",

volume = "83",

pages = "1144--1147",

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TY - JOUR

T1 - Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases

AU - Siewert, J. R.

AU - Kestlmeier, R.

AU - Busch, R.

AU - Böttcher, K.

AU - Roder, J. D.

AU - Müller, J.

AU - Fellbaum, C.

AU - Höfler, H.

PY - 1996

Y1 - 1996

N2 - A retrospective immunohistological analysis of 100 patients with pT(1- 3) N0 and pT(1-3) N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastrict cancer surgery in patients with lymph node metastasis.

AB - A retrospective immunohistological analysis of 100 patients with pT(1- 3) N0 and pT(1-3) N1 gastric adenocarcinoma demonstrated a high frequency of micro-involvement in the removed lymph nodes. The presence of three or more tumour cells in more than 10 per cent of the lymph nodes was of significant prognostic value in the pN0 cases. Multivariate analysis identified micro-involvement as an independent prognostic factor. The results explain why patients benefit from lymphadenectomy even if the removed lymph nodes are not involved by tumour (pN0) in routine histological examination. The frequent occurrence of micro-involvement is a strong argument favouring routine D2 lymph node dissection in gastrict cancer surgery in patients with lymph node metastasis.

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Benefits of D₂ lymph node dissection for patients with gastric cancer and pN₀ and pN₁ lymph node metastases

Abstract

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