Beeinflussung der Vorphase der Gerinnung durch Dextran 150 - II. Mitteilung In vivo-Studien am Kaninchen

Henner Graeff, Walter Kuhn, Ursula Borgstedt, Christel Freese

Research output: Contribution to journalArticlepeer-review

Abstract

Infusion of Dextran 150 in rabbits induced in the beginning a shortening of the r-time in the thrombelastogram, a decline of the platelets and a shortening of the coagulation time in the thromboplastin formation test. Later a prolongation of the r-time in the TEG and a prolongation of the coagulation time in the thromboplastin formation test without further altering of the platelet count are seen. It might be assumed according to the statistical calculation of probabilities, that these datas can be reproduced. The tests used support the view that Dextran 150 influences the clotting system via a contactproduct. In the second part of the experiment there is evidence of an inhibitor which delays the increased intravascular process of coagulation. The connections between that and other inhibitors of clotting mechanism known in the literature are discussed.

Original languageGerman
Pages (from-to)646-650
Number of pages5
JournalKlinische Wochenschrift
Volume44
Issue number11
DOIs
StatePublished - Jun 1966
Externally publishedYes

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