BEEINFLUSSUNG DER FENOTEROL-INDUZIERTEN NIERENFUNKTIONSSTORUNG DURCH METOPROLOL

Translated title of the contribution: Influence on fenoterol renal function disturbance by metoprolol

U. Kuhn, W. Kuhn, G. Grospietsch

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The effect on renal function of a combination of β2 receptor stimulating tocolytic agent (Fenoterol) with a so-called cardioselective β1 blocker (Metoprolol) which is able to antagonise the cardiac side effects of β2 stimulation, was examined in female rabbits in a 24-hour test. Infusing 31.5 ml/h isotonic solution, 20 μg/kg/min Fenoterol and 3.125 μg/kg/min Metoprolol, excretion, creatinine clearance, electrolyte elimination, the serum electrolyte levels, Hb, HK and the weight were determined. The combination of Fenoterol and Metoprolol antagonised almost completely the massive water retention occurring under Fenoterol alone. At the latest after 12 hours, normal values were obtained in respect of the creatinine clearance reduced under Fenoterol, the urine excretion rate and, consequently, the Hb concentration and haematocrit reading. The reduction of sodium elimination caused by Fenoterol was completely reversed under the combination, whereas the reduced excretion of potassium was not influenced. Water retention in tocolysis with β2 stimulants is one of the most important causes for the formation of a pulmonary oedema. The danger of the occurrence of such pulmonary oedemas, especially in risk pregnancies (gestosis), is drastically reduced by antagonising water retention, and hence the combination of Fenoterol and Metoprolol seems to be very favourable from both the cardiac and renal viewpoints. In a group of 17 pregnant women, the drastic improvemement of urine excretion under the combination could be confirmed.

Translated title of the contributionInfluence on fenoterol renal function disturbance by metoprolol
Original languageGerman
Pages (from-to)104-110
Number of pages7
JournalGeburtshilfe und Frauenheilkunde
Volume43
Issue numberSpec. Iss. 1
DOIs
StatePublished - 1983
Externally publishedYes

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