Bedeutung der klonalen Hämatopoese für hämatologische Neoplasien

Translated title of the contribution: Importance of clonal hematopoiesis for hematologic neoplasms

Katharina S. Götze, Claudia Lengerke

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Background: Clonal hematopoiesis of indeterminate potential (CHIP) is a fairly newly described phenomenon characterized by myeloid cancer-associated somatic mutations detectable in the peripheral blood of individuals without evidence of hematologic disease. Individuals with CHIP have a significantly increased risk of developing a hematologic malignancy, although the overall rate of transformation is low. Objective: We review the current state of knowledge on causes of clonal expansion of blood cells as well as identifiable risk factors for progression to overt hematologic malignancy. Results and conclusion: CHIP is considered a premalignant state and predisposes to the development of hematologic malignancy. Because the overall rate of transformation is low, clear identification and subsequent monitoring of those CHIP individuals at a higher risk is of paramount importance. In the future, prospective studies evaluating preventive and/or preemptive therapeutic strategies may aid in avoiding progression to blood cancer in individuals with CHIP.

Translated title of the contributionImportance of clonal hematopoiesis for hematologic neoplasms
Original languageGerman
Pages (from-to)1107-1114
Number of pages8
JournalInnere Medizin (Germany)
Issue number11
StatePublished - Nov 2022


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