Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations

H. Wiendl; K. V. Toyka; P. Rieckmann; R. Gold; H. P. Hartung; R. Hohlfeld; U. Baumhackl; T. Berger; F. Deisenhammer; F. Fazekas; M. Freimüller; H. Kollegger; W. Kristoferitsch; H. Lassmann; H. Markut; S. Strasser-Fuchs; K. Vass; C. Sindic; M. B. D'hooghe; S. Podobnik; E. Havrdova; I. Elovaara; M. Clanet; C. Confavreux; G. Edan; C. Lubetzki; H. Altenkirch; S. Bamborschke; K. Baum; A. Bayas; R. Benecke; W. Brück; M. Buttmann; A. Chan; M. Daumer; D. Dommasch; W. G. Elias; E. Fasshauer; P. Flachenecker; J. Haas; G. Haferkamp; P. Haller; C. Heesen; M. Heibel; F. Heidenreich; B. Hemmer; T. Henze; R. W.C. Janzen; G. Japp; S. Jung; E. Jügelt; B. Kallmann; B. C. Kieseier; C. Kleinschnitz; J. Köhler; W. Köhler; W. Kölmel; N. König; G. Lehrieder; V. Leussink; K. Lowitzsch; M. Mäurer; U. Manegold; A. Melms; J. Mertin; S. G. Meuth; O. Neuhaus; P. Oschmann; H. F. Petereit; M. Pette; D. Pöhlau; D. Pohl; K. Ruprecht; M. Sailer; H. Schipper; S. Schmidt; G. Schock; M. Schulz; S. Schwarz; G. Schwendemann; D. Seidel; N. Sommer; M. Stangel; E. Stark; A. Steinbrecher; G. Stoll; H. Tumani; R. Voltz; F. Weber; F. Weilbach; H. Wiethölter; B. Wildemann; U. K. Zettl; T. Ziemssen; F. Zipp; R. Zschenderlein; A. Orologas; A. Guseo; S. Bergmann; M. Pugliatti; K. M. Myhr; G. Izquierdo; C. Bassetti; K. Beer; S. Beer; U. Buettner; M. Chofflon; A. Gass; N. Goebels; M. Götschi-Fuchs; L. Kappos; J. Kesselring; H. P. Ludin; H. Mattle; M. Schluep; C. Vaney; D. Bates

doi:10.1007/s00415-008-0061-1

Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations

H. Wiendl, K. V. Toyka, P. Rieckmann, R. Gold, H. P. Hartung, R. Hohlfeld, U. Baumhackl, T. Berger, F. Deisenhammer, F. Fazekas, M. Freimüller, H. Kollegger, W. Kristoferitsch, H. Lassmann, H. Markut, S. Strasser-Fuchs, K. Vass, C. Sindic, M. B. D'hooghe, S. PodobnikE. Havrdova, I. Elovaara, M. Clanet, C. Confavreux, G. Edan, C. Lubetzki, H. Altenkirch, S. Bamborschke, K. Baum, A. Bayas, R. Benecke, W. Brück, M. Buttmann, A. Chan, M. Daumer, D. Dommasch, W. G. Elias, E. Fasshauer, P. Flachenecker, J. Haas, G. Haferkamp, P. Haller, C. Heesen, M. Heibel, F. Heidenreich, B. Hemmer, T. Henze, R. W.C. Janzen, G. Japp, S. Jung, E. Jügelt, B. Kallmann, B. C. Kieseier, C. Kleinschnitz, J. Köhler, W. Köhler, W. Kölmel, N. König, G. Lehrieder, V. Leussink, K. Lowitzsch, M. Mäurer, U. Manegold, A. Melms, J. Mertin, S. G. Meuth, O. Neuhaus, P. Oschmann, H. F. Petereit, M. Pette, D. Pöhlau, D. Pohl, K. Ruprecht, M. Sailer, H. Schipper, S. Schmidt, G. Schock, M. Schulz, S. Schwarz, G. Schwendemann, D. Seidel, N. Sommer, M. Stangel, E. Stark, A. Steinbrecher, G. Stoll, H. Tumani, R. Voltz, F. Weber, F. Weilbach, H. Wiethölter, B. Wildemann, U. K. Zettl, T. Ziemssen, F. Zipp, R. Zschenderlein, A. Orologas, A. Guseo, S. Bergmann, M. Pugliatti, K. M. Myhr, G. Izquierdo, C. Bassetti, K. Beer, S. Beer, U. Buettner, M. Chofflon, A. Gass, N. Goebels, M. Götschi-Fuchs, L. Kappos, J. Kesselring, H. P. Ludin, H. Mattle, M. Schluep, C. Vaney, D. Bates

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Abstract

This review updates and extends earlier Consensus Reports related to current basic and escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature has been extracted for new evidence from randomized controlled trials, open treatment studies and reported expert opinion, both in original articles and reviews, and evaluates indications and safety issues based on published data. After data extraction from published full length publications and critically weighing the evidence and potential impact of the data, the review has been drafted and circulated within the National MS Societies and the European MS Platform to reach consensus within a very large group of European experts, combining evidence-based criteria and expert opinion where evidence is still incomplete. The review also outlines a few areas of controversy and delineates the need for future research.

Original language	English
Pages (from-to)	1449-1463
Number of pages	15
Journal	Journal of Neurology
Volume	255
Issue number	10
DOIs	https://doi.org/10.1007/s00415-008-0061-1
State	Published - Oct 2008

Keywords

Glatirameracetate
Immunotherapy
Interferon β
Monoclonal antibodies
Multiple sclerosis
Randomized trials
Treatment escalation

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10.1007/s00415-008-0061-1

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Wiendl, H., Toyka, K. V., Rieckmann, P., Gold, R., Hartung, H. P., Hohlfeld, R., Baumhackl, U., Berger, T., Deisenhammer, F., Fazekas, F., Freimüller, M., Kollegger, H., Kristoferitsch, W., Lassmann, H., Markut, H., Strasser-Fuchs, S., Vass, K., Sindic, C., D'hooghe, M. B., ... Bates, D. (2008). Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations. Journal of Neurology, 255(10), 1449-1463. https://doi.org/10.1007/s00415-008-0061-1

@article{f308c7412cc747dbb9c76f3cdb60433f,

title = "Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations",

abstract = "This review updates and extends earlier Consensus Reports related to current basic and escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature has been extracted for new evidence from randomized controlled trials, open treatment studies and reported expert opinion, both in original articles and reviews, and evaluates indications and safety issues based on published data. After data extraction from published full length publications and critically weighing the evidence and potential impact of the data, the review has been drafted and circulated within the National MS Societies and the European MS Platform to reach consensus within a very large group of European experts, combining evidence-based criteria and expert opinion where evidence is still incomplete. The review also outlines a few areas of controversy and delineates the need for future research.",

keywords = "Glatirameracetate, Immunotherapy, Interferon β, Monoclonal antibodies, Multiple sclerosis, Randomized trials, Treatment escalation",

author = "H. Wiendl and Toyka, {K. V.} and P. Rieckmann and R. Gold and Hartung, {H. P.} and R. Hohlfeld and U. Baumhackl and T. Berger and F. Deisenhammer and F. Fazekas and M. Freim{\"u}ller and H. Kollegger and W. Kristoferitsch and H. Lassmann and H. Markut and S. Strasser-Fuchs and K. Vass and C. Sindic and D'hooghe, {M. B.} and S. Podobnik and E. Havrdova and I. Elovaara and M. Clanet and C. Confavreux and G. Edan and C. Lubetzki and H. Altenkirch and S. Bamborschke and K. Baum and A. Bayas and R. Benecke and W. Br{\"u}ck and M. Buttmann and A. Chan and M. Daumer and D. Dommasch and Elias, {W. G.} and E. Fasshauer and P. Flachenecker and J. Haas and G. Haferkamp and P. Haller and C. Heesen and M. Heibel and F. Heidenreich and B. Hemmer and T. Henze and Janzen, {R. W.C.} and G. Japp and S. Jung and E. J{\"u}gelt and B. Kallmann and Kieseier, {B. C.} and C. Kleinschnitz and J. K{\"o}hler and W. K{\"o}hler and W. K{\"o}lmel and N. K{\"o}nig and G. Lehrieder and V. Leussink and K. Lowitzsch and M. M{\"a}urer and U. Manegold and A. Melms and J. Mertin and Meuth, {S. G.} and O. Neuhaus and P. Oschmann and Petereit, {H. F.} and M. Pette and D. P{\"o}hlau and D. Pohl and K. Ruprecht and M. Sailer and H. Schipper and S. Schmidt and G. Schock and M. Schulz and S. Schwarz and G. Schwendemann and D. Seidel and N. Sommer and M. Stangel and E. Stark and A. Steinbrecher and G. Stoll and H. Tumani and R. Voltz and F. Weber and F. Weilbach and H. Wieth{\"o}lter and B. Wildemann and Zettl, {U. K.} and T. Ziemssen and F. Zipp and R. Zschenderlein and A. Orologas and A. Guseo and S. Bergmann and M. Pugliatti and Myhr, {K. M.} and G. Izquierdo and C. Bassetti and K. Beer and S. Beer and U. Buettner and M. Chofflon and A. Gass and N. Goebels and M. G{\"o}tschi-Fuchs and L. Kappos and J. Kesselring and Ludin, {H. P.} and H. Mattle and M. Schluep and C. Vaney and D. Bates",

year = "2008",

month = oct,

doi = "10.1007/s00415-008-0061-1",

language = "English",

volume = "255",

pages = "1449--1463",

journal = "Journal of Neurology",

issn = "0340-5354",

number = "10",

}

Wiendl, H, Toyka, KV, Rieckmann, P, Gold, R, Hartung, HP, Hohlfeld, R, Baumhackl, U, Berger, T, Deisenhammer, F, Fazekas, F, Freimüller, M, Kollegger, H, Kristoferitsch, W, Lassmann, H, Markut, H, Strasser-Fuchs, S, Vass, K, Sindic, C, D'hooghe, MB, Podobnik, S, Havrdova, E, Elovaara, I, Clanet, M, Confavreux, C, Edan, G, Lubetzki, C, Altenkirch, H, Bamborschke, S, Baum, K, Bayas, A, Benecke, R, Brück, W, Buttmann, M, Chan, A, Daumer, M, Dommasch, D, Elias, WG, Fasshauer, E, Flachenecker, P, Haas, J, Haferkamp, G, Haller, P, Heesen, C, Heibel, M, Heidenreich, F, Hemmer, B, Henze, T, Janzen, RWC, Japp, G, Jung, S, Jügelt, E, Kallmann, B, Kieseier, BC, Kleinschnitz, C, Köhler, J, Köhler, W, Kölmel, W, König, N, Lehrieder, G, Leussink, V, Lowitzsch, K, Mäurer, M, Manegold, U, Melms, A, Mertin, J, Meuth, SG, Neuhaus, O, Oschmann, P, Petereit, HF, Pette, M, Pöhlau, D, Pohl, D, Ruprecht, K, Sailer, M, Schipper, H, Schmidt, S, Schock, G, Schulz, M, Schwarz, S, Schwendemann, G, Seidel, D, Sommer, N, Stangel, M, Stark, E, Steinbrecher, A, Stoll, G, Tumani, H, Voltz, R, Weber, F, Weilbach, F, Wiethölter, H, Wildemann, B, Zettl, UK, Ziemssen, T, Zipp, F, Zschenderlein, R, Orologas, A, Guseo, A, Bergmann, S, Pugliatti, M, Myhr, KM, Izquierdo, G, Bassetti, C, Beer, K, Beer, S, Buettner, U, Chofflon, M, Gass, A, Goebels, N, Götschi-Fuchs, M, Kappos, L, Kesselring, J, Ludin, HP, Mattle, H, Schluep, M, Vaney, C & Bates, D 2008, 'Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations', Journal of Neurology, vol. 255, no. 10, pp. 1449-1463. https://doi.org/10.1007/s00415-008-0061-1

TY - JOUR

T1 - Basic and escalating immunomodulatory treatments in multiple sclerosis

T2 - Current therapeutic recommendations

AU - Wiendl, H.

AU - Toyka, K. V.

AU - Rieckmann, P.

AU - Gold, R.

AU - Hartung, H. P.

AU - Hohlfeld, R.

AU - Baumhackl, U.

AU - Berger, T.

AU - Deisenhammer, F.

AU - Fazekas, F.

AU - Freimüller, M.

AU - Kollegger, H.

AU - Kristoferitsch, W.

AU - Lassmann, H.

AU - Markut, H.

AU - Strasser-Fuchs, S.

AU - Vass, K.

AU - Sindic, C.

AU - D'hooghe, M. B.

AU - Podobnik, S.

AU - Havrdova, E.

AU - Elovaara, I.

AU - Clanet, M.

AU - Confavreux, C.

AU - Edan, G.

AU - Lubetzki, C.

AU - Altenkirch, H.

AU - Bamborschke, S.

AU - Baum, K.

AU - Bayas, A.

AU - Benecke, R.

AU - Brück, W.

AU - Buttmann, M.

AU - Chan, A.

AU - Daumer, M.

AU - Dommasch, D.

AU - Elias, W. G.

AU - Fasshauer, E.

AU - Flachenecker, P.

AU - Haas, J.

AU - Haferkamp, G.

AU - Haller, P.

AU - Heesen, C.

AU - Heibel, M.

AU - Heidenreich, F.

AU - Hemmer, B.

AU - Henze, T.

AU - Janzen, R. W.C.

AU - Japp, G.

AU - Jung, S.

AU - Jügelt, E.

AU - Kallmann, B.

AU - Kieseier, B. C.

AU - Kleinschnitz, C.

AU - Köhler, J.

AU - Köhler, W.

AU - Kölmel, W.

AU - König, N.

AU - Lehrieder, G.

AU - Leussink, V.

AU - Lowitzsch, K.

AU - Mäurer, M.

AU - Manegold, U.

AU - Melms, A.

AU - Mertin, J.

AU - Meuth, S. G.

AU - Neuhaus, O.

AU - Oschmann, P.

AU - Petereit, H. F.

AU - Pette, M.

AU - Pöhlau, D.

AU - Pohl, D.

AU - Ruprecht, K.

AU - Sailer, M.

AU - Schipper, H.

AU - Schmidt, S.

AU - Schock, G.

AU - Schulz, M.

AU - Schwarz, S.

AU - Schwendemann, G.

AU - Seidel, D.

AU - Sommer, N.

AU - Stangel, M.

AU - Stark, E.

AU - Steinbrecher, A.

AU - Stoll, G.

AU - Tumani, H.

AU - Voltz, R.

AU - Weber, F.

AU - Weilbach, F.

AU - Wiethölter, H.

AU - Wildemann, B.

AU - Zettl, U. K.

AU - Ziemssen, T.

AU - Zipp, F.

AU - Zschenderlein, R.

AU - Orologas, A.

AU - Guseo, A.

AU - Bergmann, S.

AU - Pugliatti, M.

AU - Myhr, K. M.

AU - Izquierdo, G.

AU - Bassetti, C.

AU - Beer, K.

AU - Beer, S.

AU - Buettner, U.

AU - Chofflon, M.

AU - Gass, A.

AU - Goebels, N.

AU - Götschi-Fuchs, M.

AU - Kappos, L.

AU - Kesselring, J.

AU - Ludin, H. P.

AU - Mattle, H.

AU - Schluep, M.

AU - Vaney, C.

AU - Bates, D.

PY - 2008/10

Y1 - 2008/10

N2 - This review updates and extends earlier Consensus Reports related to current basic and escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature has been extracted for new evidence from randomized controlled trials, open treatment studies and reported expert opinion, both in original articles and reviews, and evaluates indications and safety issues based on published data. After data extraction from published full length publications and critically weighing the evidence and potential impact of the data, the review has been drafted and circulated within the National MS Societies and the European MS Platform to reach consensus within a very large group of European experts, combining evidence-based criteria and expert opinion where evidence is still incomplete. The review also outlines a few areas of controversy and delineates the need for future research.

AB - This review updates and extends earlier Consensus Reports related to current basic and escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature has been extracted for new evidence from randomized controlled trials, open treatment studies and reported expert opinion, both in original articles and reviews, and evaluates indications and safety issues based on published data. After data extraction from published full length publications and critically weighing the evidence and potential impact of the data, the review has been drafted and circulated within the National MS Societies and the European MS Platform to reach consensus within a very large group of European experts, combining evidence-based criteria and expert opinion where evidence is still incomplete. The review also outlines a few areas of controversy and delineates the need for future research.

KW - Glatirameracetate

KW - Immunotherapy

KW - Interferon β

KW - Monoclonal antibodies

KW - Multiple sclerosis

KW - Randomized trials

KW - Treatment escalation

UR - http://www.scopus.com/inward/record.url?scp=56349150992&partnerID=8YFLogxK

U2 - 10.1007/s00415-008-0061-1

DO - 10.1007/s00415-008-0061-1

M3 - Review article

C2 - 19005625

AN - SCOPUS:56349150992

SN - 0340-5354

VL - 255

SP - 1449

EP - 1463

JO - Journal of Neurology

JF - Journal of Neurology

IS - 10

ER -

Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations

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Keywords

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