Base-catalyzed hydroamination of aromatic olefins - An efficient route to 1-aryl-4-(arylethyl)piperazines

Matthias Beller, Claudia Breindl

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

An efficient synthesis of pharmaceutically interesting 1-aryl-4- (arylethyl)-piperazines by base-catalyzed hydroamination is presented. Starting from substituted aryl olefins and various N-arylpiperazines, the desired products 3 - 12 were obtained in one step under mild conditions in the presence of a catalytic amount of n-butyllithium in yields up to 99%.

Original languageEnglish
Pages (from-to)6359-6368
Number of pages10
JournalTetrahedron
Volume54
Issue number23
DOIs
StatePublished - 4 Jun 1998
Externally publishedYes

Keywords

  • 1-aryl-4- (arylethyl)piperazines
  • Anti-Markovnikov amination
  • Base-catalyzed hydroamination

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