B7-H3 and its role in antitumor immunity

Jörg Kleeff, Martin Loos, Dennis M. Hedderich, Helmut Friess

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations


B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.

Original languageEnglish
Article number683875
JournalClinical and Developmental Immunology
StatePublished - 2010
Externally publishedYes


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