Axonal regeneration: Role of growth and guidance cues

M. Bähr, P. Lingor

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


During embryogenesis, developing axons are guided by a complex interplay of repellent and attractive molecules to establish functional connections with target regions. Axon guidance molecules, such as ephrins, semaphorins, slits, and netrins, but also morphogens and growth factors, participate in this process. Persistent repulsive guidance cues, myelin-derived outgrowth inhibitors, and lack of tropic factors are major factors creating a nonpermissive environment for axonal regeneration in the lesioned adult mammalian central nervous system. The modulation of inhibitory pathways and intrinsic proregenerative programs may thus be instrumental in therapeutic approaches for traumatic and degenerative neurological diseases.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages10
ISBN (Print)9780080450469
StatePublished - 2009
Externally publishedYes


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