Axon guidance: Receptor complexes and signaling mechanisms

Ilona C. Grunwald, Rüdiger Klein

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

The generation of a functional neuronal network requires that axons navigate precisely to their appropriate targets. Molecules that specify guidance decisions have been identified, and the signaling events that occur downstream of guidance receptors are beginning to be understood. New research shows that guidance receptor signaling can be hierarchical - one receptor silencing the other - thereby allowing navigating growth cones to interpret opposing guidance cues. Among the known intracellular signaling molecules shared by all guidance receptor families, Rho GTPases appear to be primary regulators of actin dynamics and growth cone guidance. Novel effector molecules complete the picture and suggest additional signaling mechanisms.

Original languageEnglish
Pages (from-to)250-259
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume12
Issue number3
DOIs
StatePublished - 1 Jun 2002
Externally publishedYes

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