Automatic volumetry can reveal visually undetected disease features on brain MR images in temporal lobe epilepsy

S. Keihaninejad, R. A. Heckemann, I. S. Gousias, P. Aljabar, J. V. Hajnal, D. Rueckert, A. Hammers

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

Brain structural volumes can be used for automatically classifying subjects into categories like controls and patients. We aimed to automatically separate patients with temporal lobe epilepsy (TLE) with and without hippocampal atrophy on MRI, pTLE and nTLE, from controls, and determine the epileptogenic side. In the proposed framework 83 brain structure volumes are identified using multi-atlas segmentation. We then use structure selection using a divergence measure and classification based on structural volumes, as well as morphological similarities using SVM. A spectral analysis step is used to convert the pairwise measures of similarity between subjects into per-subject features. Up to 96% of pTLE patients were correctly separated from controls using 14 structural brain volumes. The classification method based on spectral analysis was 91% accurate at separating nTLE patients from controls. Right and left hippocampus were sufficient for the lateralization of the seizure focus in the pTLE group and achieved 100% accuracy.

Original languageEnglish
Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2010 - Proceedings
Pages105-108
Number of pages4
DOIs
StatePublished - 2010
Externally publishedYes
Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
Duration: 14 Apr 201017 Apr 2010

Publication series

Name2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Conference

Conference7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
Country/TerritoryNetherlands
CityRotterdam
Period14/04/1017/04/10

Keywords

  • Classification
  • Segmentation
  • Spectral analysis
  • Support vector machine
  • Temporal lobe epilepsy

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