Autoimmune encephalitis and gastrointestinal dysmotility: Achalasia, gastroparesis, and slow transit constipation

Thomas Frieling; Christian Kreysel; Michael Blank; Dorothee Müller; Ilka Melchior; Philipp Euler; Rita Kuhlbusch-Zicklam; Thomas Haarmeier; Michael Schemann

doi:10.1055/a-1233-2190

Autoimmune encephalitis and gastrointestinal dysmotility: Achalasia, gastroparesis, and slow transit constipation

Translated title of the contribution: Autoimmune encephalitis and gastrointestinal dysmotility: Achalasia, gastroparesis, and slow transit constipation

Thomas Frieling, Christian Kreysel, Michael Blank, Dorothee Müller, Ilka Melchior, Philipp Euler, Rita Kuhlbusch-Zicklam, Thomas Haarmeier, Michael Schemann

Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background Neurological autoimmune disorders (NAD) are caused by autoimmune inflammation triggered by specific antibody subtypes. NADmay disturb the gut-brain axis at several levels including brain, spinal cord, peripheral, or enteric nervous system. Case report We present a case with antinuclear neuronal Hu (ANNA-1)- and antiglial nuclear (SOX-1) autoimmune antibody- positive limbic encephalitis and significant gastrointestinal dysmotility consisting of achalasia type II, gastroparesis, altered small intestinal interdigestive motility, and severe slow transit constipation. The autoantibodies of the patient s serumlabeled enteric neurons and interstitial cells of Cajal but no other cells in the gut wall. Achalasia was treated successfully by pneumatic cardia dilation and gastrointestinal dysmotility successfully with prucalopride. Conclusion NADmay disturb gastrointestinal motility by altering various levels of the gut-brain axis.

Translated title of the contribution	Autoimmune encephalitis and gastrointestinal dysmotility: Achalasia, gastroparesis, and slow transit constipation
Original language	English
Pages (from-to)	975-981
Number of pages	7
Journal	Zeitschrift fur Gastroenterologie
Volume	58
Issue number	10
DOIs	https://doi.org/10.1055/a-1233-2190
State	Published - 1 Oct 2020

Keywords

ANNA-1
achalasia
anti-Hu
autoimmune antibodies
autoimmune encephalitis
gastroparesis
limbic encephalitis
slow transit constipation

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title = "Autoimmune encephalitis and gastrointestinal dysmotility: Achalasia, gastroparesis, and slow transit constipation",

abstract = "Background Neurological autoimmune disorders (NAD) are caused by autoimmune inflammation triggered by specific antibody subtypes. NADmay disturb the gut-brain axis at several levels including brain, spinal cord, peripheral, or enteric nervous system. Case report We present a case with antinuclear neuronal Hu (ANNA-1)- and antiglial nuclear (SOX-1) autoimmune antibody- positive limbic encephalitis and significant gastrointestinal dysmotility consisting of achalasia type II, gastroparesis, altered small intestinal interdigestive motility, and severe slow transit constipation. The autoantibodies of the patient s serumlabeled enteric neurons and interstitial cells of Cajal but no other cells in the gut wall. Achalasia was treated successfully by pneumatic cardia dilation and gastrointestinal dysmotility successfully with prucalopride. Conclusion NADmay disturb gastrointestinal motility by altering various levels of the gut-brain axis.",

keywords = "ANNA-1, achalasia, anti-Hu, autoimmune antibodies, autoimmune encephalitis, gastroparesis, limbic encephalitis, slow transit constipation",

author = "Thomas Frieling and Christian Kreysel and Michael Blank and Dorothee M{\"u}ller and Ilka Melchior and Philipp Euler and Rita Kuhlbusch-Zicklam and Thomas Haarmeier and Michael Schemann",

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month = oct,

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doi = "10.1055/a-1233-2190",

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T1 - Autoimmune encephalitis and gastrointestinal dysmotility

T2 - Achalasia, gastroparesis, and slow transit constipation

AU - Frieling, Thomas

AU - Kreysel, Christian

AU - Blank, Michael

AU - Müller, Dorothee

AU - Melchior, Ilka

AU - Euler, Philipp

AU - Kuhlbusch-Zicklam, Rita

AU - Haarmeier, Thomas

AU - Schemann, Michael

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Background Neurological autoimmune disorders (NAD) are caused by autoimmune inflammation triggered by specific antibody subtypes. NADmay disturb the gut-brain axis at several levels including brain, spinal cord, peripheral, or enteric nervous system. Case report We present a case with antinuclear neuronal Hu (ANNA-1)- and antiglial nuclear (SOX-1) autoimmune antibody- positive limbic encephalitis and significant gastrointestinal dysmotility consisting of achalasia type II, gastroparesis, altered small intestinal interdigestive motility, and severe slow transit constipation. The autoantibodies of the patient s serumlabeled enteric neurons and interstitial cells of Cajal but no other cells in the gut wall. Achalasia was treated successfully by pneumatic cardia dilation and gastrointestinal dysmotility successfully with prucalopride. Conclusion NADmay disturb gastrointestinal motility by altering various levels of the gut-brain axis.

AB - Background Neurological autoimmune disorders (NAD) are caused by autoimmune inflammation triggered by specific antibody subtypes. NADmay disturb the gut-brain axis at several levels including brain, spinal cord, peripheral, or enteric nervous system. Case report We present a case with antinuclear neuronal Hu (ANNA-1)- and antiglial nuclear (SOX-1) autoimmune antibody- positive limbic encephalitis and significant gastrointestinal dysmotility consisting of achalasia type II, gastroparesis, altered small intestinal interdigestive motility, and severe slow transit constipation. The autoantibodies of the patient s serumlabeled enteric neurons and interstitial cells of Cajal but no other cells in the gut wall. Achalasia was treated successfully by pneumatic cardia dilation and gastrointestinal dysmotility successfully with prucalopride. Conclusion NADmay disturb gastrointestinal motility by altering various levels of the gut-brain axis.

KW - ANNA-1

KW - achalasia

KW - anti-Hu

KW - autoimmune antibodies

KW - autoimmune encephalitis

KW - gastroparesis

KW - limbic encephalitis

KW - slow transit constipation

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DO - 10.1055/a-1233-2190

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AN - SCOPUS:85092754394

SN - 0044-2771

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JO - Zeitschrift fur Gastroenterologie

JF - Zeitschrift fur Gastroenterologie

IS - 10

ER -

Autoimmune encephalitis and gastrointestinal dysmotility: Achalasia, gastroparesis, and slow transit constipation

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