AUTOANTIBODIES AGAINST PARATHYROID HORMONE IN A PATIENT WITH TERMINAL RENAL INSUFFICIENCY

H. Jüppner; R. Baethke; M. J. Atkinson; R. D. Hesch

doi:10.1016/S0140-6736(84)91875-0

AUTOANTIBODIES AGAINST PARATHYROID HORMONE IN A PATIENT WITH TERMINAL RENAL INSUFFICIENCY

H. Jüppner
, R. Baethke
, M. J. Atkinson
, R. D. Hesch

Medizinische Hochschule Hannover
Peter Friedrich Ludwigs Hospital

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

An autoantibody against mid-C-regional, possibly mid-regional, parathyroid hormone was detected in the plasma of a patient with terminal renal insufficiency who was on intermittent haemodialysis. 43-68(Tyr)hPTH and 42-55(Tyr)hPTH were selectively bound by his IgG fraction. 43-68(Tyr)hPTH had the highest affinity for the autoantibody; intact parathyroid hormone did not displace radiolabelled 42-55(Tyr)hPTH or 43-68(Tyr)hPTH. As concentrations of circulating antibodies against mid-C/mid-regional parathyroid hormone fell rises in intact and mid-C-regional parathyroid hormone levels and in alkaline phosphatase activity were observed. This autoantibody directed against the middle portion of the parathyroid hormone molecule seemed to have some protective properties against the osteoblast-stimulating activity of the hormone, implying that the mid-C-region or middle region of the molecule has some biological importance.

Original language	English
Pages (from-to)	1379-1381
Number of pages	3
Journal	The Lancet
Volume	323
Issue number	8391
DOIs	https://doi.org/10.1016/S0140-6736(84)91875-0
State	Published - 23 Jun 1984
Externally published	Yes

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title = "AUTOANTIBODIES AGAINST PARATHYROID HORMONE IN A PATIENT WITH TERMINAL RENAL INSUFFICIENCY",

abstract = "An autoantibody against mid-C-regional, possibly mid-regional, parathyroid hormone was detected in the plasma of a patient with terminal renal insufficiency who was on intermittent haemodialysis. 43-68(Tyr)hPTH and 42-55(Tyr)hPTH were selectively bound by his IgG fraction. 43-68(Tyr)hPTH had the highest affinity for the autoantibody; intact parathyroid hormone did not displace radiolabelled 42-55(Tyr)hPTH or 43-68(Tyr)hPTH. As concentrations of circulating antibodies against mid-C/mid-regional parathyroid hormone fell rises in intact and mid-C-regional parathyroid hormone levels and in alkaline phosphatase activity were observed. This autoantibody directed against the middle portion of the parathyroid hormone molecule seemed to have some protective properties against the osteoblast-stimulating activity of the hormone, implying that the mid-C-region or middle region of the molecule has some biological importance.",

author = "H. J{\"u}ppner and R. Baethke and Atkinson, \{M. J.\} and Hesch, \{R. D.\}",

year = "1984",

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AU - Jüppner, H.

AU - Baethke, R.

AU - Atkinson, M. J.

AU - Hesch, R. D.

PY - 1984/6/23

Y1 - 1984/6/23

N2 - An autoantibody against mid-C-regional, possibly mid-regional, parathyroid hormone was detected in the plasma of a patient with terminal renal insufficiency who was on intermittent haemodialysis. 43-68(Tyr)hPTH and 42-55(Tyr)hPTH were selectively bound by his IgG fraction. 43-68(Tyr)hPTH had the highest affinity for the autoantibody; intact parathyroid hormone did not displace radiolabelled 42-55(Tyr)hPTH or 43-68(Tyr)hPTH. As concentrations of circulating antibodies against mid-C/mid-regional parathyroid hormone fell rises in intact and mid-C-regional parathyroid hormone levels and in alkaline phosphatase activity were observed. This autoantibody directed against the middle portion of the parathyroid hormone molecule seemed to have some protective properties against the osteoblast-stimulating activity of the hormone, implying that the mid-C-region or middle region of the molecule has some biological importance.

AB - An autoantibody against mid-C-regional, possibly mid-regional, parathyroid hormone was detected in the plasma of a patient with terminal renal insufficiency who was on intermittent haemodialysis. 43-68(Tyr)hPTH and 42-55(Tyr)hPTH were selectively bound by his IgG fraction. 43-68(Tyr)hPTH had the highest affinity for the autoantibody; intact parathyroid hormone did not displace radiolabelled 42-55(Tyr)hPTH or 43-68(Tyr)hPTH. As concentrations of circulating antibodies against mid-C/mid-regional parathyroid hormone fell rises in intact and mid-C-regional parathyroid hormone levels and in alkaline phosphatase activity were observed. This autoantibody directed against the middle portion of the parathyroid hormone molecule seemed to have some protective properties against the osteoblast-stimulating activity of the hormone, implying that the mid-C-region or middle region of the molecule has some biological importance.

UR - https://www.scopus.com/pages/publications/0021273114

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DO - 10.1016/S0140-6736(84)91875-0

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SN - 0140-6736

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JO - The Lancet

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IS - 8391

ER -

AUTOANTIBODIES AGAINST PARATHYROID HORMONE IN A PATIENT WITH TERMINAL RENAL INSUFFICIENCY

Abstract

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