Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7)

Understanding Society Scientific Group

doi:10.1038/s41588-024-01752-4

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7)

Understanding Society Scientific Group

University of Leicester
and University of Melbourne Department of Medical Biology and School of Mathematics and Statistics
University of Melbourne
Brigham and Women's Hospital
GlaxoSmithKline, USA
Siriraj Hospital
University of Arizona College of Medicine – Tucson
University of Oxford Medical Sciences Division
University of Oxford
The University of British Columbia Centre for Heart Lung Innovation
University of Cambridge
Imperial College London
University Medicine Greifswald
The University of Edinburgh Medical School
University of Edinburgh, College of Medicine and Veterinary Medicine
University of Liverpool
Flatiron Institute
Sir Charles Gardiner Hospital
University of Western Australia
Helmholtz Zentrum München German Research Center for Environmental Health
Ludwig-Maximilians-Universität München
Member of the German Center for Lung Research (DZL)
Swiss Tropical and Public Health Institute (Swiss TPH)
University of Basel
University of Edinburgh
MRC Human Genetics Unit
Uppsala University
University of Helsinki
National Institute for Health and Welfare
Fimlab Laboratories
University of Bergen
Johns Hopkins Bloomberg School of Public Health
Laval University
Université Laval
University Medical Center Groningen
National Jewish Health
Addenbrooke's Hospital
Wellcome Sanger Institute
St Mary’s Hospital
Mount Sinai School of Medicine
University of Colorado Denver
MRC Epidemiology Unit
Peking University Health Science Center
DNAX Research Institute
University of Aberdeen
Gossamer Bio
University of Münster
University of Nottingham
University of British Columbia
Ninewells Hospital and Medical School
Universitat Autònoma de Barcelona
Hospital Universitari Vall d'Hebron
Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
VA Boston Healthcare System
Boston University School of Medicine
Cellzome GmbH
University of California San Francisco
Department of Chemical Engineering
Princeton University
Turku University Hospital
University of Turku
Tampere University Hospital
University of Split Medical School
The University of Western Australia
Faculty of Medicine
University of Oulu
Oulu University Hospital
College of Health and Life Sciences
St. George's University of London
Glenfield Hospital

Research output: Contribution to journal › Comment/debate

Abstract

Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-018-0321-7, published online 25 February 2019. In the version of the article initially published, unconsented individuals were erroneously included in SPIROMICS consortium results. The analysis has now been repeated with the unconsented individuals removed. The change in the results does not affect the conclusions in the paper. The corrections required to the paper are as follows: In the third paragraph of the “Association with FEV₁/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10^–75” should be “P = 2.21 × 10^–75”. In the fourth paragraph of the “Association with FEV₁/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10⁻⁴³”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10⁻⁴³”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10^–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10^–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10^–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10^–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. In the third paragraph of the “Association with FEV₁/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10^–75” should be “P = 2.21 × 10^–75”. In the fourth paragraph of the “Association with FEV₁/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10⁻⁴³”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10⁻⁴³”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10^–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10^–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10^–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10^–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. The correction is due to 26 unconsented SPIROMICS samples being originally included in the analysis. The analyses that previously included these samples have been rerun with data from these 26 samples removed. Supplementary Information accompanies the online version of this amendment and includes: Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data. Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data.

Original language	English
Pages (from-to)	1032-1033
Number of pages	2
Journal	Nature Genetics
Volume	56
Issue number	5
DOIs	https://doi.org/10.1038/s41588-024-01752-4
State	Published - May 2024
Externally published	Yes

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@article{756ec3832e3a46ef9cb1ad58c34acff6,

title = "Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7)",

abstract = "Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-018-0321-7, published online 25 February 2019. In the version of the article initially published, unconsented individuals were erroneously included in SPIROMICS consortium results. The analysis has now been repeated with the unconsented individuals removed. The change in the results does not affect the conclusions in the paper. The corrections required to the paper are as follows: In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95\% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95\% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95\% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95\% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. The correction is due to 26 unconsented SPIROMICS samples being originally included in the analysis. The analyses that previously included these samples have been rerun with data from these 26 samples removed. Supplementary Information accompanies the online version of this amendment and includes: Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data. Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data.",

author = "\{Understanding Society Scientific Group\} and Nick Shrine and Guyatt, \{Anna L.\} and Erzurumluoglu, \{A. Mesut\} and Jackson, \{Victoria E.\} and Hobbs, \{Brian D.\} and Melbourne, \{Carl A.\} and Chiara Batini and Fawcett, \{Katherine A.\} and Kijoung Song and Phuwanat Sakornsakolpat and Xingnan Li and Ruth Boxall and Reeve, \{Nicola F.\} and Ma{\textquoteright}en Obeidat and Zhao, \{Jing Hua\} and Matthias Wielscher and Stefan Weiss and Kentistou, \{Katherine A.\} and Cook, \{James P.\} and Sun, \{Benjamin B.\} and Jian Zhou and Jennie Hui and Stefan Karrasch and Medea Imboden and Harris, \{Sarah E.\} and Jonathan Marten and Stefan Enroth and Kerr, \{Shona M.\} and Ida Surakka and Veronique Vitart and Terho Lehtim{\"a}ki and Allen, \{Richard J.\} and Bakke, \{Per S.\} and Beaty, \{Terri H.\} and Bleecker, \{Eugene R.\} and Yohan Boss{\'e} and Brandsma, \{Corry Anke\} and Zhengming Chen and Crapo, \{James D.\} and John Danesh and DeMeo, \{Dawn L.\} and Frank Dudbridge and Ralf Ewert and Christian Gieger and Amund Gulsvik and Hansell, \{Anna L.\} and Ke Hao and Hoffman, \{Joshua D.\} and Hokanson, \{John E.\} and Eleftheria Zeggini",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.",

year = "2024",

month = may,

doi = "10.1038/s41588-024-01752-4",

language = "English",

volume = "56",

pages = "1032--1033",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

}

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7). / Understanding Society Scientific Group.
In: Nature Genetics, Vol. 56, No. 5, 05.2024, p. 1032-1033.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Author Correction

T2 - New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7)

AU - Understanding Society Scientific Group

AU - Shrine, Nick

AU - Guyatt, Anna L.

AU - Erzurumluoglu, A. Mesut

AU - Jackson, Victoria E.

AU - Hobbs, Brian D.

AU - Melbourne, Carl A.

AU - Batini, Chiara

AU - Fawcett, Katherine A.

AU - Song, Kijoung

AU - Sakornsakolpat, Phuwanat

AU - Li, Xingnan

AU - Boxall, Ruth

AU - Reeve, Nicola F.

AU - Obeidat, Ma’en

AU - Zhao, Jing Hua

AU - Wielscher, Matthias

AU - Weiss, Stefan

AU - Kentistou, Katherine A.

AU - Cook, James P.

AU - Sun, Benjamin B.

AU - Zhou, Jian

AU - Hui, Jennie

AU - Karrasch, Stefan

AU - Imboden, Medea

AU - Harris, Sarah E.

AU - Marten, Jonathan

AU - Enroth, Stefan

AU - Kerr, Shona M.

AU - Surakka, Ida

AU - Vitart, Veronique

AU - Lehtimäki, Terho

AU - Allen, Richard J.

AU - Bakke, Per S.

AU - Beaty, Terri H.

AU - Bleecker, Eugene R.

AU - Bossé, Yohan

AU - Brandsma, Corry Anke

AU - Chen, Zhengming

AU - Crapo, James D.

AU - Danesh, John

AU - DeMeo, Dawn L.

AU - Dudbridge, Frank

AU - Ewert, Ralf

AU - Gieger, Christian

AU - Gulsvik, Amund

AU - Hansell, Anna L.

AU - Hao, Ke

AU - Hoffman, Joshua D.

AU - Hokanson, John E.

AU - Zeggini, Eleftheria

PY - 2024/5

Y1 - 2024/5

N2 - Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-018-0321-7, published online 25 February 2019. In the version of the article initially published, unconsented individuals were erroneously included in SPIROMICS consortium results. The analysis has now been repeated with the unconsented individuals removed. The change in the results does not affect the conclusions in the paper. The corrections required to the paper are as follows: In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. The correction is due to 26 unconsented SPIROMICS samples being originally included in the analysis. The analyses that previously included these samples have been rerun with data from these 26 samples removed. Supplementary Information accompanies the online version of this amendment and includes: Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data. Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data.

AB - Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-018-0321-7, published online 25 February 2019. In the version of the article initially published, unconsented individuals were erroneously included in SPIROMICS consortium results. The analysis has now been repeated with the unconsented individuals removed. The change in the results does not affect the conclusions in the paper. The corrections required to the paper are as follows: In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. The correction is due to 26 unconsented SPIROMICS samples being originally included in the analysis. The analyses that previously included these samples have been rerun with data from these 26 samples removed. Supplementary Information accompanies the online version of this amendment and includes: Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data. Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data.

UR - https://www.scopus.com/pages/publications/85192394658

U2 - 10.1038/s41588-024-01752-4

DO - 10.1038/s41588-024-01752-4

M3 - Comment/debate

C2 - 38641645

AN - SCOPUS:85192394658

SN - 1061-4036

VL - 56

SP - 1032

EP - 1033

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7)

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