Aurora kinases A and B and familial breast cancer risk

Sandrine Tchatchou; Michael Wirtenberger; Kari Hemminki; Christian Sutter; Alfons Meindl; Barbara Wappenschmidt; Marion Kiechle; Peter Bugert; Rita K. Schmutzler; Claus R. Bartram; Barbara Burwinkel

doi:10.1016/j.canlet.2006.05.002

Aurora kinases A and B and familial breast cancer risk

Sandrine Tchatchou, Michael Wirtenberger, Kari Hemminki, Christian Sutter, Alfons Meindl, Barbara Wappenschmidt, Marion Kiechle, Peter Bugert, Rita K. Schmutzler, Claus R. Bartram, Barbara Burwinkel

Chair of Gynaecology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05-2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.

Original language	English
Pages (from-to)	266-272
Number of pages	7
Journal	Cancer Letters
Volume	247
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2006.05.002
State	Published - 18 Mar 2007

Keywords

Aurora kinases
Breast cancer
Case-control study
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2006.05.002

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title = "Aurora kinases A and B and familial breast cancer risk",

abstract = "Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05-2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.",

keywords = "Aurora kinases, Breast cancer, Case-control study, Polymorphism",

author = "Sandrine Tchatchou and Michael Wirtenberger and Kari Hemminki and Christian Sutter and Alfons Meindl and Barbara Wappenschmidt and Marion Kiechle and Peter Bugert and Schmutzler, {Rita K.} and Bartram, {Claus R.} and Barbara Burwinkel",

note = "Funding Information: The authors are grateful to Bernd Frank for support. The German BC samples were collected within a project funded by the Deutsche Krebshilfe and coordinated by Prof. Rita K. Schmutzler. It was supported by the Center of Molecular Medicine Cologne (CMMC) and the EU, LSHC-CT-2004-5034.",

year = "2007",

month = mar,

day = "18",

doi = "10.1016/j.canlet.2006.05.002",

language = "English",

volume = "247",

pages = "266--272",

journal = "Cancer Letters",

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T1 - Aurora kinases A and B and familial breast cancer risk

AU - Tchatchou, Sandrine

AU - Wirtenberger, Michael

AU - Hemminki, Kari

AU - Sutter, Christian

AU - Meindl, Alfons

AU - Wappenschmidt, Barbara

AU - Kiechle, Marion

AU - Bugert, Peter

AU - Schmutzler, Rita K.

AU - Bartram, Claus R.

AU - Burwinkel, Barbara

N1 - Funding Information: The authors are grateful to Bernd Frank for support. The German BC samples were collected within a project funded by the Deutsche Krebshilfe and coordinated by Prof. Rita K. Schmutzler. It was supported by the Center of Molecular Medicine Cologne (CMMC) and the EU, LSHC-CT-2004-5034.

PY - 2007/3/18

Y1 - 2007/3/18

N2 - Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05-2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.

AB - Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05-2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.

KW - Aurora kinases

KW - Breast cancer

KW - Case-control study

KW - Polymorphism

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U2 - 10.1016/j.canlet.2006.05.002

DO - 10.1016/j.canlet.2006.05.002

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SN - 0304-3835

VL - 247

SP - 266

EP - 272

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Aurora kinases A and B and familial breast cancer risk

Abstract

Keywords

UN SDGs

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