Atopic eczema: role of microorganisms on the skin surface

J. Ring, D. Abeck, K. Neuber

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

The pathophysiology of atopic eczema (AE) is still poorly understood. One possible concept favors IgE‐mediated reactivity towards allergens that enter the skin from the outside or through the blood. Microorganisms of the cutaneous flora also might represent a stimulus for allergic skin reactions. Abnormal bacterial skin colonization is a characteristic feature of AE. Staphylococcus aureus (S. aureus) is the most common pathogen. Binding to host cells involves special receptors, such as fibronectin or laminin. Specific IgE antibodies to S. aureus can be detected in the blood. Whereas the clinical relevance of anti‐staphylococcal antibodies is still controversial, specific IgE antibodies to Pityrosporum species as well as positive type I prick test reactions to these yeasts seem to correlate with the intensity of eczematous lesions in the head and neck regions of patients with AE. Both antimicrobial and antifungal treatment has been shown helpful in some cases of AE.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume47
Issue number4
DOIs
StatePublished - Aug 1992
Externally publishedYes

Keywords

  • Pityrosporum ovale
  • Staphylococcus aureus
  • atopic eczema
  • skin microorganisms
  • specific IgE antibodies

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