Abstract
We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining the binding affinity of DNA proteins in dependence with the target DNA sequence for further correlative studies on physical affinity and biological relevance of the controlled gene. Furthermore, force spectroscopy is a powerful analytical tool to investigate structural and functional features of biomolecules. Altogether, these tools have revealed useful application in genomics and proteomics.
| Original language | English |
|---|---|
| Pages (from-to) | 71-76 |
| Number of pages | 6 |
| Journal | Cancer Genomics and Proteomics |
| Volume | 1 |
| Issue number | 1 |
| State | Published - 2004 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- AFM
- Force spectroscopy
- Protein-DNA complex
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