Atlas selection strategy for automatic segmentation of pediatric brain MRIs into 83 ROIs

Ioannis S. Gousias, Alexander Hammers, Rolf A. Heckemann, Serena J. Counsell, Leigh E. Dyet, James P. Boardman, A. David Edwards, Daniel Rueckert

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Scopus citations

Abstract

Registration algorithms can facilitate the automatic anatomical segmentation of pediatric brain MR data sets when segmentation priors (atlases) are in hand. Automatic segmentation can be achieved through label propagation and label fusion in target space. We investigated the performance of different age cohorts used as prior atlases for the segmentation of 13 MRIs of 1-year-olds. Thirty adults and 33 2-year-olds (including the 13 1-year olds, scanned a year later) served as priors for label propagation and fusion. In addition, we tested the accuracy of a single propagation step of the atlas of the same subject scanned at 2 years of age. Pediatric priors performed better than adult priors on visual inspection as well as manual validation of the caudate nucleus (Dice index=0.89±0.02 vs. 0.86±0.03). Corresponding single atlases at the age of 2 performed better than the fusion of 30 adult priors (83 ROIs / average Dice=0.87±0.05 vs. 0.84±0.07).

Original languageEnglish
Title of host publication2010 IEEE International Conference on Imaging Systems and Techniques, IST 2010 - Proceedings
Pages290-293
Number of pages4
DOIs
StatePublished - 2010
Externally publishedYes
Event2010 IEEE International Conference on Imaging Systems and Techniques, IST 2010 - Thessaloniki, Greece
Duration: 1 Jul 20102 Jul 2010

Publication series

Name2010 IEEE International Conference on Imaging Systems and Techniques, IST 2010 - Proceedings

Conference

Conference2010 IEEE International Conference on Imaging Systems and Techniques, IST 2010
Country/TerritoryGreece
CityThessaloniki
Period1/07/102/07/10

Keywords

  • Brain atlases
  • Brain segmentation
  • Non-rigid registration
  • Parameters
  • Pediatric brain atlasing
  • Priors
  • Validation

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