TY - JOUR
T1 - Associations between single nucleotide polymorphisms and total energy, carbohydrate, and fat intakes
T2 - A systematic review
AU - Drabsch, Theresa
AU - Gatzemeier, Jennifer
AU - Pfadenhauer, Lisa
AU - Hauner, Hans
AU - Holzapfel, Christina
N1 - Publisher Copyright:
© 2018 American Society for Nutrition.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - A better understanding of the genetic underpinning of total energy, carbohydrate, and fat intake is a prerequisite to develop personalized dietary recommendations. For this purpose, we systematically reviewed associations between single nucleotide polymorphisms (SNPs) and total energy, carbohydrate, and fat intakes. Four databases were searched for studies that assessed an association between SNPs and total energy, carbohydrate, and fat intakes. Screening of articles and data extraction was performed independently by 2 reviewers. Articles in English or German language, published between 1994 and September 2017, on human studies in adults andwithout specific populationswere considered for the review. In total, 39 articles, including 86 independent loci, met the inclusion criteria. The fat mass and obesity-associated (FTO) gene as well as the melanocortin 4 receptor (MC4R) locus were most frequently studied. Limited significant evidence of an association between the FTO SNP rs9939609 and lower total energy intake and between the MC4R SNP rs17782313 and higher total energy intake was reported. Most of the other identified loci showed inconsistent results. In conclusion, there is no consistent evidence that the investigated SNPs are associated with and predictive for total energy, carbohydrate, and fat intakes.
AB - A better understanding of the genetic underpinning of total energy, carbohydrate, and fat intake is a prerequisite to develop personalized dietary recommendations. For this purpose, we systematically reviewed associations between single nucleotide polymorphisms (SNPs) and total energy, carbohydrate, and fat intakes. Four databases were searched for studies that assessed an association between SNPs and total energy, carbohydrate, and fat intakes. Screening of articles and data extraction was performed independently by 2 reviewers. Articles in English or German language, published between 1994 and September 2017, on human studies in adults andwithout specific populationswere considered for the review. In total, 39 articles, including 86 independent loci, met the inclusion criteria. The fat mass and obesity-associated (FTO) gene as well as the melanocortin 4 receptor (MC4R) locus were most frequently studied. Limited significant evidence of an association between the FTO SNP rs9939609 and lower total energy intake and between the MC4R SNP rs17782313 and higher total energy intake was reported. Most of the other identified loci showed inconsistent results. In conclusion, there is no consistent evidence that the investigated SNPs are associated with and predictive for total energy, carbohydrate, and fat intakes.
KW - Carbohydrate intake
KW - Energy intake
KW - Fat intake
KW - Genetic variant
KW - Nutrigenomic
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=85060951349&partnerID=8YFLogxK
U2 - 10.1093/advances/nmy024
DO - 10.1093/advances/nmy024
M3 - Review article
C2 - 30032228
AN - SCOPUS:85060951349
SN - 2161-8313
VL - 9
SP - 425
EP - 453
JO - Advances in Nutrition
JF - Advances in Nutrition
IS - 4
ER -