TY - JOUR
T1 - Association of persistent organic pollutants with sensorimotor neuropathy in participants with and without diabetes or prediabetes
T2 - Results from the population-based KORA FF4 study
AU - Schwarz, Maximilian
AU - Wolf, Kathrin
AU - Schneider, Alexandra
AU - Schramm, Karl Werner
AU - Bongaerts, Brenda
AU - Henkelmann, Bernhard
AU - Herder, Christian
AU - Roden, Michael
AU - Peters, Annette
AU - Ziegler, Dan
AU - Rathmann, Wolfgang
N1 - Publisher Copyright:
© 2021 Elsevier GmbH
PY - 2021/6
Y1 - 2021/6
N2 - Background: Concentrations of persistent organic pollutants (POPs) have been associated with an increased type 2 diabetes (T2D) risk. It remains unclear whether POPs are also associated with the risk of diabetes complications including neuropathy and evidence on this topic is scarce. We aimed to investigate the hypothesis that low-dose background concentrations of POPs were positively associated with distal sensorimotor polyneuropathy (DSPN). Methods: This cross-sectional study was based on data from the second follow-up (FF4, 2013–2014, N = 2279) of the population-based KORA S4 study (Augsburg, Germany). The study sample consisted of 200 participants, including four groups of 50 persons each with known T2D, prediabetes, newly diagnosed diabetes, and normal glucose tolerance (NGT) based on an oral glucose tolerance test. We analyzed the association of six most abundant serum concentrations of POPs, including polychlorinated biphenyls (PCBs) as well as organochlorine (OC) pesticides, with DSPN by multivariable logistic regression adjusted for age, sex, glycaemic status, body mass index, physical activity, smoking and alcohol consumption. We assessed effect modification by age, sex, glycaemic status and obesity and conducted two-pollutant models to check the robustness of the estimates. Results: For all pollutants, the main models indicated no significant association of having DSPN but pointed to rather decreased odds for DSPN. Two-pollutant models supported these findings, though only the association between the combination of PCB-138 and beta-hexachlorocyclohexane (β-HCH) (OR: 0.59; 95% CI: 0.35–0.99) with DSPN became significant. No effect modification was found by age, sex, glycaemic status and obesity. Conclusion: Low-dose concentrations of POPs were not associated with increased odds of having DSPN in T2D, prediabetes and NGT.
AB - Background: Concentrations of persistent organic pollutants (POPs) have been associated with an increased type 2 diabetes (T2D) risk. It remains unclear whether POPs are also associated with the risk of diabetes complications including neuropathy and evidence on this topic is scarce. We aimed to investigate the hypothesis that low-dose background concentrations of POPs were positively associated with distal sensorimotor polyneuropathy (DSPN). Methods: This cross-sectional study was based on data from the second follow-up (FF4, 2013–2014, N = 2279) of the population-based KORA S4 study (Augsburg, Germany). The study sample consisted of 200 participants, including four groups of 50 persons each with known T2D, prediabetes, newly diagnosed diabetes, and normal glucose tolerance (NGT) based on an oral glucose tolerance test. We analyzed the association of six most abundant serum concentrations of POPs, including polychlorinated biphenyls (PCBs) as well as organochlorine (OC) pesticides, with DSPN by multivariable logistic regression adjusted for age, sex, glycaemic status, body mass index, physical activity, smoking and alcohol consumption. We assessed effect modification by age, sex, glycaemic status and obesity and conducted two-pollutant models to check the robustness of the estimates. Results: For all pollutants, the main models indicated no significant association of having DSPN but pointed to rather decreased odds for DSPN. Two-pollutant models supported these findings, though only the association between the combination of PCB-138 and beta-hexachlorocyclohexane (β-HCH) (OR: 0.59; 95% CI: 0.35–0.99) with DSPN became significant. No effect modification was found by age, sex, glycaemic status and obesity. Conclusion: Low-dose concentrations of POPs were not associated with increased odds of having DSPN in T2D, prediabetes and NGT.
KW - Diabetes
KW - KORA
KW - Peripheral polyneuropathy
KW - Persistent organic pollutant
KW - Polyneuropathy
UR - http://www.scopus.com/inward/record.url?scp=85106345107&partnerID=8YFLogxK
U2 - 10.1016/j.ijheh.2021.113752
DO - 10.1016/j.ijheh.2021.113752
M3 - Article
C2 - 34020228
AN - SCOPUS:85106345107
SN - 1438-4639
VL - 235
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
M1 - 113752
ER -