Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

Dimitrios C. Karampinos; Stefan Ruschke; Olga Gordijenko; Eduardo Grande Garcia; Hendrik Kooijman; Rainer Burgkart; Ernst J. Rummeny; Jan S. Bauer; Thomas Baum

doi:10.1155/2015/152349

Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

Dimitrios C. Karampinos, Stefan Ruschke, Olga Gordijenko, Eduardo Grande Garcia, Hendrik Kooijman, Rainer Burgkart, Ernst J. Rummeny, Jan S. Bauer, Thomas Baum

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Abstract

Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.

Original language	English
Article number	152349
Journal	Journal of Osteoporosis
Volume	2015
DOIs	https://doi.org/10.1155/2015/152349
State	Published - 2015

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title = "Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model",

abstract = "Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.",

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T1 - Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

AU - Karampinos, Dimitrios C.

AU - Ruschke, Stefan

AU - Gordijenko, Olga

AU - Grande Garcia, Eduardo

AU - Kooijman, Hendrik

AU - Burgkart, Rainer

AU - Rummeny, Ernst J.

AU - Bauer, Jan S.

AU - Baum, Thomas

PY - 2015

Y1 - 2015

N2 - Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.

AB - Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.

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VL - 2015

JO - Journal of Osteoporosis

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Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

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