Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults

Stephan Weidinger, N. Klopp, L. Rümmler, S. Wagenpfeil, H. J. Baurecht, A. Gauger, U. Darsow, T. Jakob, N. Novak, T. Schäfer, J. Heinrich, H. Behrendt, H. E. Wichmann, J. Ring, T. Illig

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69 Scopus citations

Abstract

Background: Influences of microbial pathogens are crucial for the maturation of the immune system. Caspase-recruitment domain containing protein 15 (CARD 15) is a cytosolic receptor involved in bacterial recognition by antigen-presenting cells. CARD15 polymorphisms have been associated with Crohn's disease. Recently, associations with atopic phenotypes have been reported in children. Objective: Within a large population of German adults (n = 1875), we evaluated eight CARD15 polymorphisms for associations with atopic phenotypes. Methods: Subjects were phenotyped by standardized questionnaires and interviews as well as total and allergen-specific IgE measurements. Genotyping was performed using matrix-assisted laser desorption ionization - time of flight mass spectrometry. Haplotypes were estimated using the SAS/Genetics module. Results: Subjects with a T allele at rs1077861 had a decreased risk of developing asthma (odds ratio OR = 0.648, P = 0.013), whereas the presence of an A allele at rs3135500 was significantly associated with an increased risk (OR = 1.374, P = 0.023). In addition, a CARD15 haplotype revealed to be protective against the development of asthma (OR = 0.326, P = 0.003). Subjects with an A allele at position rs5743266 or a T allele at rs2066842 had a significantly decreased risk of developing allergic rhinoconjunctivitis with ORs of 0.820 (P = 0.049) and 0.801 (P = 0.025). Polymorphism rs2066845 showed a significant association with increased total serum IgE (OR = 2.155, P = 0.006). Conclusion: Genetic variants of CARD15 that might result in inappropriate immunomodulation are not only associated with autoimmune diseases but also with atopic disorders.

Original languageEnglish
Pages (from-to)866-872
Number of pages7
JournalClinical and Experimental Allergy
Volume35
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • Allergic rhinoconjunctivitis
  • Asthma
  • Atopic eczema
  • Atopy
  • CARD15
  • Haplotype
  • IgE
  • NOD2
  • SNP

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