Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Elise M.A. Slob; Alen Faiz; Jos van Nijnatten; Susanne J.H. Vijverberg; Cristina Longo; Merve Kutlu; Fook Tim Chew; Yang Yie Sio; Esther Herrera-Luis; Antonio Espuela-Ortiz; Javier Perez-Garcia; Maria Pino-Yanes; Esteban G. Burchard; Uroš Potočnik; Mario Gorenjak; Colin Palmer; Cyrielle Maroteau; Steve Turner; Katia Verhamme; Leila Karimi; Somnath Mukhopadhyay; Wim Timens; Pieter S. Hiemstra; Mariëlle W. Pijnenburg; Margaret Neighbors; Michele A. Grimbaldeston; Gaik W. Tew; Corry A. Brandsma; Vojko Berce; Hananeh Aliee; Fabian Theis; Don D. Sin; Xuan Li; Maarten van den Berge; Anke H. Maitland-van der Zee; Gerard H. Koppelman

doi:10.1002/clt2.12173

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Elise M.A. Slob, Alen Faiz, Jos van Nijnatten, Susanne J.H. Vijverberg, Cristina Longo, Merve Kutlu, Fook Tim Chew, Yang Yie Sio, Esther Herrera-Luis, Antonio Espuela-Ortiz, Javier Perez-Garcia, Maria Pino-Yanes, Esteban G. Burchard, Uroš Potočnik, Mario Gorenjak, Colin Palmer, Cyrielle Maroteau, Steve Turner, Katia Verhamme, Leila KarimiSomnath Mukhopadhyay, Wim Timens, Pieter S. Hiemstra, Mariëlle W. Pijnenburg, Margaret Neighbors, Michele A. Grimbaldeston, Gaik W. Tew, Corry A. Brandsma, Vojko Berce, Hananeh Aliee, Fabian Theis, Don D. Sin, Xuan Li, Maarten van den Berge, Anke H. Maitland-van der Zee, Gerard H. Koppelman

Chair of Mathematical Modelling of Biological Systems

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Original language	English
Article number	e12173
Journal	Clinical and Translational Allergy
Volume	12
Issue number	8
DOIs	https://doi.org/10.1002/clt2.12173
State	Published - Aug 2022

Keywords

children
exacerbations
inhaled corticosteroids
methylation quantitative trait loci (meQTL)
pharmacogenetics

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10.1002/clt2.12173

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Slob, E. M. A., Faiz, A., van Nijnatten, J., Vijverberg, S. J. H., Longo, C., Kutlu, M., Chew, F. T., Sio, Y. Y., Herrera-Luis, E., Espuela-Ortiz, A., Perez-Garcia, J., Pino-Yanes, M., Burchard, E. G., Potočnik, U., Gorenjak, M., Palmer, C., Maroteau, C., Turner, S., Verhamme, K., ... Koppelman, G. H. (2022). Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response. Clinical and Translational Allergy, 12(8), Article e12173. https://doi.org/10.1002/clt2.12173

@article{bb3865fa661b4e858cf1c1a1782b8141,

title = "Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response",

keywords = "children, exacerbations, inhaled corticosteroids, methylation quantitative trait loci (meQTL), pharmacogenetics",

author = "Slob, {Elise M.A.} and Alen Faiz and {van Nijnatten}, Jos and Vijverberg, {Susanne J.H.} and Cristina Longo and Merve Kutlu and Chew, {Fook Tim} and Sio, {Yang Yie} and Esther Herrera-Luis and Antonio Espuela-Ortiz and Javier Perez-Garcia and Maria Pino-Yanes and Burchard, {Esteban G.} and Uro{\v s} Poto{\v c}nik and Mario Gorenjak and Colin Palmer and Cyrielle Maroteau and Steve Turner and Katia Verhamme and Leila Karimi and Somnath Mukhopadhyay and Wim Timens and Hiemstra, {Pieter S.} and Pijnenburg, {Mari{\"e}lle W.} and Margaret Neighbors and Grimbaldeston, {Michele A.} and Tew, {Gaik W.} and Brandsma, {Corry A.} and Vojko Berce and Hananeh Aliee and Fabian Theis and Sin, {Don D.} and Xuan Li and {van den Berge}, Maarten and {Maitland-van der Zee}, {Anke H.} and Koppelman, {Gerard H.}",

note = "Funding Information: The GLUCOLD study (for which these are secondary analyses) was supported by the Netherlands Organisation for Scientific Research (NWO), the Dutch Asthma Foundation, GlaxoSmithKline, the University Medical Center Groningen, and Leiden University Medical Center. Genentech Inc. funded the GLUCOLD bronchial biopsy RNA sequencing project. E.M.A. Slob, S.J.H. Vijverberg, A.H. Maitland‐van der Zee, G.H. Koppelman and M.W. Pijnenburg are conducting the PUFFIN trial that is supported by the Lung Foundation Netherlands, grant number 5.1.16.094. The PACMAN cohort study was funded by a strategic alliance between GlaxoSmithKline and Utrecht Institute for Pharmaceutical Sciences. The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3‐0067) and from the SysPharmPedia grant, co‐financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330‐16‐500106). The Genes‐environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes and Environments (SAGE) were supported in part by the Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II, the National Heart, Lung, and Blood Institute of the National Institutes of Health R01HL117004, R01HL128439, R01HL135156, X01HL134589, R01HL141992, R01HL141845, National Institute of Health and Environmental Health Sciences R01ES015794, R21ES24844, the National Institute on Minority Health and Health Disparities P60MD006902, RL5GM118984, R01MD010443, and R56MD013312, the Tobacco‐Related Disease Research Program under Award Number 24RT‐0025, 27IR‐0030 and the National Human Genome Research Institute U01HG009080. The genotyping service of PAGES was carried out at CEGEN‐PRB3‐ISCIII, supported by grant PT17/0019 of the PE I+D+i 2013–2016, funded by ISCIII and ERDF. Maria Pino‐Yanes was funded by the Ram{\'o}n y Cajal Program by the Spanish Ministry of Science, Innovation, and Universities (MICIU) (RYC‐2015‐17205) and by a grant by MICIU, the State Research Agency, and the European Regional Development Fund from the European Union (MICIU/AEI/FEDER, UE, SAF2017‐83417R). Esther Herera‐Luis was supported by a MICIU fellowship (PRE2018‐083837). Javier Perez‐Garcia was also supported by a Ph.D. fellowship (FPU19/02175) granted by MICIU. Antonio Espuela‐Ortiz was supported by a fellowship granted by MICIU/ULL (M‐ULL). The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3‐0067) and from the SysPharmPedia grant, co‐financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330‐16‐500106). F.J. Theis reports receiving consulting fees from Roche Diagnostics GmbH and Cellarity Inc., and ownership interest in Cellarity, Inc. and Dermagnostix. Funding Information: The GLUCOLD study (for which these are secondary analyses) was supported by the Netherlands Organisation for Scientific Research (NWO), the Dutch Asthma Foundation, GlaxoSmithKline, the University Medical Center Groningen, and Leiden University Medical Center. Genentech Inc. funded the GLUCOLD bronchial biopsy RNA sequencing project. E.M.A. Slob, S.J.H. Vijverberg, A.H. Maitland-van der Zee, G.H. Koppelman and M.W. Pijnenburg are conducting the PUFFIN trial that is supported by the Lung Foundation Netherlands, grant number 5.1.16.094. The PACMAN cohort study was funded by a strategic alliance between GlaxoSmithKline and Utrecht Institute for Pharmaceutical Sciences. The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3-0067) and from the SysPharmPedia grant, co-financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330-16-500106). The Genes-environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes and Environments (SAGE) were supported in part by the Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II, the National Heart, Lung, and Blood Institute of the National Institutes of Health R01HL117004, R01HL128439, R01HL135156, X01HL134589, R01HL141992, R01HL141845, National Institute of Health and Environmental Health Sciences R01ES015794, R21ES24844, the National Institute on Minority Health and Health Disparities P60MD006902, RL5GM118984, R01MD010443, and R56MD013312, the Tobacco-Related Disease Research Program under Award Number 24RT-0025, 27IR-0030 and the National Human Genome Research Institute U01HG009080. The genotyping service of PAGES was carried out at CEGEN-PRB3-ISCIII, supported by grant PT17/0019 of the PE I+D+i 2013–2016, funded by ISCIII and ERDF. Maria Pino-Yanes was funded by the Ram{\'o}n y Cajal Program by the Spanish Ministry of Science, Innovation, and Universities (MICIU) (RYC-2015-17205) and by a grant by MICIU, the State Research Agency, and the European Regional Development Fund from the European Union (MICIU/AEI/FEDER, UE, SAF2017-83417R). Esther Herera-Luis was supported by a MICIU fellowship (PRE2018-083837). Javier Perez-Garcia was also supported by a Ph.D. fellowship (FPU19/02175) granted by MICIU. Antonio Espuela-Ortiz was supported by a fellowship granted by MICIU/ULL (M-ULL). The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3-0067) and from the SysPharmPedia grant, co-financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330-16-500106). F.J. Theis reports receiving consulting fees from Roche Diagnostics GmbH and Cellarity Inc., and ownership interest in Cellarity, Inc. and Dermagnostix.",

year = "2022",

month = aug,

doi = "10.1002/clt2.12173",

language = "English",

volume = "12",

journal = "Clinical and Translational Allergy",

issn = "2045-7022",

publisher = "John Wiley & Sons Inc.",

number = "8",

}

Slob, EMA, Faiz, A, van Nijnatten, J, Vijverberg, SJH, Longo, C, Kutlu, M, Chew, FT, Sio, YY, Herrera-Luis, E, Espuela-Ortiz, A, Perez-Garcia, J, Pino-Yanes, M, Burchard, EG, Potočnik, U, Gorenjak, M, Palmer, C, Maroteau, C, Turner, S, Verhamme, K, Karimi, L, Mukhopadhyay, S, Timens, W, Hiemstra, PS, Pijnenburg, MW, Neighbors, M, Grimbaldeston, MA, Tew, GW, Brandsma, CA, Berce, V, Aliee, H, Theis, F, Sin, DD, Li, X, van den Berge, M, Maitland-van der Zee, AH & Koppelman, GH 2022, 'Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response', Clinical and Translational Allergy, vol. 12, no. 8, e12173. https://doi.org/10.1002/clt2.12173

TY - JOUR

T1 - Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

AU - Slob, Elise M.A.

AU - Faiz, Alen

AU - van Nijnatten, Jos

AU - Vijverberg, Susanne J.H.

AU - Longo, Cristina

AU - Kutlu, Merve

AU - Chew, Fook Tim

AU - Sio, Yang Yie

AU - Herrera-Luis, Esther

AU - Espuela-Ortiz, Antonio

AU - Perez-Garcia, Javier

AU - Pino-Yanes, Maria

AU - Burchard, Esteban G.

AU - Potočnik, Uroš

AU - Gorenjak, Mario

AU - Palmer, Colin

AU - Maroteau, Cyrielle

AU - Turner, Steve

AU - Verhamme, Katia

AU - Karimi, Leila

AU - Mukhopadhyay, Somnath

AU - Timens, Wim

AU - Hiemstra, Pieter S.

AU - Pijnenburg, Mariëlle W.

AU - Neighbors, Margaret

AU - Grimbaldeston, Michele A.

AU - Tew, Gaik W.

AU - Brandsma, Corry A.

AU - Berce, Vojko

AU - Aliee, Hananeh

AU - Theis, Fabian

AU - Sin, Don D.

AU - Li, Xuan

AU - van den Berge, Maarten

AU - Maitland-van der Zee, Anke H.

AU - Koppelman, Gerard H.

N1 - Funding Information: The GLUCOLD study (for which these are secondary analyses) was supported by the Netherlands Organisation for Scientific Research (NWO), the Dutch Asthma Foundation, GlaxoSmithKline, the University Medical Center Groningen, and Leiden University Medical Center. Genentech Inc. funded the GLUCOLD bronchial biopsy RNA sequencing project. E.M.A. Slob, S.J.H. Vijverberg, A.H. Maitland‐van der Zee, G.H. Koppelman and M.W. Pijnenburg are conducting the PUFFIN trial that is supported by the Lung Foundation Netherlands, grant number 5.1.16.094. The PACMAN cohort study was funded by a strategic alliance between GlaxoSmithKline and Utrecht Institute for Pharmaceutical Sciences. The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3‐0067) and from the SysPharmPedia grant, co‐financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330‐16‐500106). The Genes‐environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes and Environments (SAGE) were supported in part by the Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II, the National Heart, Lung, and Blood Institute of the National Institutes of Health R01HL117004, R01HL128439, R01HL135156, X01HL134589, R01HL141992, R01HL141845, National Institute of Health and Environmental Health Sciences R01ES015794, R21ES24844, the National Institute on Minority Health and Health Disparities P60MD006902, RL5GM118984, R01MD010443, and R56MD013312, the Tobacco‐Related Disease Research Program under Award Number 24RT‐0025, 27IR‐0030 and the National Human Genome Research Institute U01HG009080. The genotyping service of PAGES was carried out at CEGEN‐PRB3‐ISCIII, supported by grant PT17/0019 of the PE I+D+i 2013–2016, funded by ISCIII and ERDF. Maria Pino‐Yanes was funded by the Ramón y Cajal Program by the Spanish Ministry of Science, Innovation, and Universities (MICIU) (RYC‐2015‐17205) and by a grant by MICIU, the State Research Agency, and the European Regional Development Fund from the European Union (MICIU/AEI/FEDER, UE, SAF2017‐83417R). Esther Herera‐Luis was supported by a MICIU fellowship (PRE2018‐083837). Javier Perez‐Garcia was also supported by a Ph.D. fellowship (FPU19/02175) granted by MICIU. Antonio Espuela‐Ortiz was supported by a fellowship granted by MICIU/ULL (M‐ULL). The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3‐0067) and from the SysPharmPedia grant, co‐financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330‐16‐500106). F.J. Theis reports receiving consulting fees from Roche Diagnostics GmbH and Cellarity Inc., and ownership interest in Cellarity, Inc. and Dermagnostix. Funding Information: The GLUCOLD study (for which these are secondary analyses) was supported by the Netherlands Organisation for Scientific Research (NWO), the Dutch Asthma Foundation, GlaxoSmithKline, the University Medical Center Groningen, and Leiden University Medical Center. Genentech Inc. funded the GLUCOLD bronchial biopsy RNA sequencing project. E.M.A. Slob, S.J.H. Vijverberg, A.H. Maitland-van der Zee, G.H. Koppelman and M.W. Pijnenburg are conducting the PUFFIN trial that is supported by the Lung Foundation Netherlands, grant number 5.1.16.094. The PACMAN cohort study was funded by a strategic alliance between GlaxoSmithKline and Utrecht Institute for Pharmaceutical Sciences. The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3-0067) and from the SysPharmPedia grant, co-financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330-16-500106). The Genes-environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes and Environments (SAGE) were supported in part by the Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II, the National Heart, Lung, and Blood Institute of the National Institutes of Health R01HL117004, R01HL128439, R01HL135156, X01HL134589, R01HL141992, R01HL141845, National Institute of Health and Environmental Health Sciences R01ES015794, R21ES24844, the National Institute on Minority Health and Health Disparities P60MD006902, RL5GM118984, R01MD010443, and R56MD013312, the Tobacco-Related Disease Research Program under Award Number 24RT-0025, 27IR-0030 and the National Human Genome Research Institute U01HG009080. The genotyping service of PAGES was carried out at CEGEN-PRB3-ISCIII, supported by grant PT17/0019 of the PE I+D+i 2013–2016, funded by ISCIII and ERDF. Maria Pino-Yanes was funded by the Ramón y Cajal Program by the Spanish Ministry of Science, Innovation, and Universities (MICIU) (RYC-2015-17205) and by a grant by MICIU, the State Research Agency, and the European Regional Development Fund from the European Union (MICIU/AEI/FEDER, UE, SAF2017-83417R). Esther Herera-Luis was supported by a MICIU fellowship (PRE2018-083837). Javier Perez-Garcia was also supported by a Ph.D. fellowship (FPU19/02175) granted by MICIU. Antonio Espuela-Ortiz was supported by a fellowship granted by MICIU/ULL (M-ULL). The SLOVENIA study was financially supported by the Slovenian Research Agency (research core funding No. P3-0067) and from the SysPharmPedia grant, co-financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (contract number C3330-16-500106). F.J. Theis reports receiving consulting fees from Roche Diagnostics GmbH and Cellarity Inc., and ownership interest in Cellarity, Inc. and Dermagnostix.

PY - 2022/8

Y1 - 2022/8

KW - children

KW - exacerbations

KW - inhaled corticosteroids

KW - methylation quantitative trait loci (meQTL)

KW - pharmacogenetics

UR - http://www.scopus.com/inward/record.url?scp=85136850046&partnerID=8YFLogxK

U2 - 10.1002/clt2.12173

DO - 10.1002/clt2.12173

M3 - Letter

AN - SCOPUS:85136850046

SN - 2045-7022

VL - 12

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

IS - 8

M1 - e12173

ER -

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Keywords

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