TY - JOUR
T1 - Association between anemia and falls in community-dwelling older people
T2 - Cross-sectional results from the KORA-Age study
AU - Thaler-Kall, Kathrin
AU - Döring, Angela
AU - Peters, Annette
AU - Thorand, Barbara
AU - Grill, Eva
AU - Koenig, Wolfgang
AU - Horsch, Alexander
AU - Meisinger, Christa
N1 - Funding Information:
The KORA-Age study was part of the program “Health in Old Age”, which was financed by the German Federal Ministry of Education and Research (BMBF FKZ 01ET0713). The KORA-Age project was conducted on the KORA platform (KORA, Cooperative Health Research in the Region of Augsburg), which was initiated and financed by the Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, and funded by the German Federal Ministry of Education, Science, Research and Technology as well as the State of Bavaria. The study “Functioning and Disability in Old Age” was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft) (GR 3608/1-1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
The authors would like to thank all study participants, the KORA Augsburg field staff and all members of the Institute of Epidemiology II from the Helmholtz Zentrum München who were involved in planning and/or conducting the study. This research was supported by the Graduate School of Information Science in Health (GSISH) and the TUM Graduate School.
PY - 2014/3/7
Y1 - 2014/3/7
N2 - Background: Falls and fractures are among the principal causes of disability, and mortality of older people. Therefore, identifying treatable risk factors for falls in this population is very important. Here we evaluate the association between anemia and falls in community-dwelling people aged 65 years and older. Methods. In 2009 967 community-dwelling people aged 65 years and older were included as part of the KORA-Age study. History of falls was assessed via questions derived from the National Health and Nutrition Examination Survey questionnaire. A non-fasting venous blood sample was obtained from all study participants. Anemia was defined as a hemoglobin level below 12 g/dL in women and below 13 g/dL in men according to the WHO criteria. Different logistic regression models were computed including relevant confounders such as sex, age, and disability to estimate Odds Ratios (OR) for falls. Results: In the total sample there was no significant association between anemia and falls neither in the unadjusted (OR 1.35; 95% CI 0.87-2.09) nor in the multivariable-adjusted models (OR 1.06; 95% CI 0.66-1.70). The association between continuous hemoglobin levels and falls was significant in the unadjusted model (OR per 1 SD decrease 1.36; 95% CI 1.14-1.64), but after adjustment for age and sex the association was attenuated and lost its significance (OR 1.13; 95% CI 0.92-1.38). In age- and sex-stratified analyses, no significant associations between anemia or hemoglobin levels and falls could be found. However, in joint analysis in the total sample a significantly, more than two-fold increased risk was observed after multivariable adjustment in persons with anemia and disability (OR 2.10; 95% CI 1.12-3.93) in comparison to persons without anemia and disability. Conclusions: In the present study we have not found an independent association between hemoglobin levels or anemia and falls in older people from the general population. Because there was an additive effect of anemia and disability on the occurrence of falls, blood count should be measured in disabled older men and women to identify persons, who are at particular high risk for falls.
AB - Background: Falls and fractures are among the principal causes of disability, and mortality of older people. Therefore, identifying treatable risk factors for falls in this population is very important. Here we evaluate the association between anemia and falls in community-dwelling people aged 65 years and older. Methods. In 2009 967 community-dwelling people aged 65 years and older were included as part of the KORA-Age study. History of falls was assessed via questions derived from the National Health and Nutrition Examination Survey questionnaire. A non-fasting venous blood sample was obtained from all study participants. Anemia was defined as a hemoglobin level below 12 g/dL in women and below 13 g/dL in men according to the WHO criteria. Different logistic regression models were computed including relevant confounders such as sex, age, and disability to estimate Odds Ratios (OR) for falls. Results: In the total sample there was no significant association between anemia and falls neither in the unadjusted (OR 1.35; 95% CI 0.87-2.09) nor in the multivariable-adjusted models (OR 1.06; 95% CI 0.66-1.70). The association between continuous hemoglobin levels and falls was significant in the unadjusted model (OR per 1 SD decrease 1.36; 95% CI 1.14-1.64), but after adjustment for age and sex the association was attenuated and lost its significance (OR 1.13; 95% CI 0.92-1.38). In age- and sex-stratified analyses, no significant associations between anemia or hemoglobin levels and falls could be found. However, in joint analysis in the total sample a significantly, more than two-fold increased risk was observed after multivariable adjustment in persons with anemia and disability (OR 2.10; 95% CI 1.12-3.93) in comparison to persons without anemia and disability. Conclusions: In the present study we have not found an independent association between hemoglobin levels or anemia and falls in older people from the general population. Because there was an additive effect of anemia and disability on the occurrence of falls, blood count should be measured in disabled older men and women to identify persons, who are at particular high risk for falls.
UR - http://www.scopus.com/inward/record.url?scp=84898020336&partnerID=8YFLogxK
U2 - 10.1186/1471-2318-14-29
DO - 10.1186/1471-2318-14-29
M3 - Article
C2 - 24602338
AN - SCOPUS:84898020336
SN - 1471-2318
VL - 14
JO - BMC Geriatrics
JF - BMC Geriatrics
IS - 1
M1 - 29
ER -