TY - JOUR
T1 - Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy
AU - Ohishi, Mitsuru
AU - Rakugi, Hiromi
AU - Ogihara, Toshio
AU - Schunkert, Heribert
AU - Riegger, Gunter A.J.
AU - Hense, Hans Werner
PY - 1994/10/20
Y1 - 1994/10/20
N2 - To the Editor: The report by Schunkert et al. (June 9 issue)1 was intriguing, but it did not elaborate on why the effect of the DD genotype of the angiotensin-converting-enzyme (ACE) gene on the development of left ventricular hypertrophy was stronger in normotensive subjects than in hypertensive patients. On this subject, we previously reported2 that the association between plasma ACE activity and the ACE genotypes is observed in normotensive subjects, but not in hypertensive patients, and that plasma ACE activity in hypertensive patients with the II, ID, and DD genotypes is similar to that in normotensive subjects with the DD…
AB - To the Editor: The report by Schunkert et al. (June 9 issue)1 was intriguing, but it did not elaborate on why the effect of the DD genotype of the angiotensin-converting-enzyme (ACE) gene on the development of left ventricular hypertrophy was stronger in normotensive subjects than in hypertensive patients. On this subject, we previously reported2 that the association between plasma ACE activity and the ACE genotypes is observed in normotensive subjects, but not in hypertensive patients, and that plasma ACE activity in hypertensive patients with the II, ID, and DD genotypes is similar to that in normotensive subjects with the DD…
UR - http://www.scopus.com/inward/record.url?scp=0028152670&partnerID=8YFLogxK
U2 - 10.1056/NEJM199410203311616
DO - 10.1056/NEJM199410203311616
M3 - Letter
C2 - 7993479
AN - SCOPUS:0028152670
SN - 0028-4793
VL - 331
SP - 1097
EP - 1098
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 16
ER -