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Assessment of murine heart function post myocardial infraction with volumetric optoacoustic tomography

  • Ivana Ivankovic
  • , Xosé Luís Deán-Ben
  • , Helena Hass
  • , Melanie A. Kimm
  • , Moritz Wildgruber
  • , Daniel Razansky
  • University of Zurich
  • ETH Zurich
  • University of Munich
  • UniversitA tsklinikum MA nster

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The heart undergoes complex remodeling processes post myocardial infarction (MI), which are yet to be fully understood. Advanced preclinical in vivo imaging tools are key to a better understanding of the processes underlying ischemic damage and cardiac remodeling. Herein, volumetric optoacoustic tomography (VOT) was used to study remodeling patterns at different stages post MI by measuring the pulmonary transit time, ICG perfusion and cardiac cycle irregularities. The real-time, non-invasive, volumetric capabilities of VOT detected differences in remodeling patterns across different MI models, highlighting the feasibility of VOT as a preclinical cardiac imaging tool to study complex murine heart dynamics.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2021
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510641198
DOIs
StatePublished - 2021
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2021 - Virtual, Online, United States
Duration: 6 Mar 202111 Mar 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11642
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2021
Country/TerritoryUnited States
CityVirtual, Online
Period6/03/2111/03/21

Keywords

  • Cardiac Imaging
  • Mouse Models
  • Myocardial Infarction.
  • Optoacoustic Imaging

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