TY - JOUR
T1 - Assessment of global and regional left ventricular function by electrocardiographic gated N-13 ammonia positron emission tomography in patients with coronary artery disease
AU - Kanayama, Sugako
AU - Matsunari, Ichiro
AU - Hirayama, Akira
AU - Kitayama, Michihiko
AU - Matsudaira, Masamichi
AU - Yoneyama, Tatsuya
AU - Nekolla, Stephan G.
AU - Hisada, Kinichi
AU - Kajinami, Koji
AU - Takekoshi, Noboru
PY - 2005/2
Y1 - 2005/2
N2 - Background: Electrocardiographic gated 13N-ammonia positron emission tomography (PET) enables simultaneous assessment of myocardial blood flow and left ventricular (LV) function. The aim of this study was to assess the accuracy of gated 13N-ammonia PET for evaluating global and regional LV function in patients with coronary artery disease (CAD) in comparison with conventional left ventriculography (LVG). Methods and Results: Fifty-four patients with CAD underwent gated 13N-ammonia PET and LVG. The LV end-diastolic and end-systolic volumes (LVEDV, LVESV) and ejection fraction (LVEF) by gated 13N-ammonia PET were calculated using Cedars-Sinai automated quantitative gated single photon emission computed tomography (QGS) and compared with those obtained by LVG. The regional wall motion (RWM) was visually scored, and compared with that on LVG. There were good correlations between the 2 methods for LVEF, LVEDV and LVESV (R=0.828, R=0.821 and R=0.874 respectively). The RWM assessed by gated 13N-ammonia PET also agreed well with that by LVG (complete agreement was 70.4%, K=0.58). Conclusions: Gated 13N-ammonia PET combined with QGS works reasonably well for the assessment of both global and regional LV function in CAD patients, although additional calibration may be necessary.
AB - Background: Electrocardiographic gated 13N-ammonia positron emission tomography (PET) enables simultaneous assessment of myocardial blood flow and left ventricular (LV) function. The aim of this study was to assess the accuracy of gated 13N-ammonia PET for evaluating global and regional LV function in patients with coronary artery disease (CAD) in comparison with conventional left ventriculography (LVG). Methods and Results: Fifty-four patients with CAD underwent gated 13N-ammonia PET and LVG. The LV end-diastolic and end-systolic volumes (LVEDV, LVESV) and ejection fraction (LVEF) by gated 13N-ammonia PET were calculated using Cedars-Sinai automated quantitative gated single photon emission computed tomography (QGS) and compared with those obtained by LVG. The regional wall motion (RWM) was visually scored, and compared with that on LVG. There were good correlations between the 2 methods for LVEF, LVEDV and LVESV (R=0.828, R=0.821 and R=0.874 respectively). The RWM assessed by gated 13N-ammonia PET also agreed well with that by LVG (complete agreement was 70.4%, K=0.58). Conclusions: Gated 13N-ammonia PET combined with QGS works reasonably well for the assessment of both global and regional LV function in CAD patients, although additional calibration may be necessary.
KW - Coronary artery disease
KW - Gated-N-ammonia positron emission tomography
KW - Left ventricular function
UR - http://www.scopus.com/inward/record.url?scp=20044387018&partnerID=8YFLogxK
U2 - 10.1253/circj.69.177
DO - 10.1253/circj.69.177
M3 - Article
C2 - 15671609
AN - SCOPUS:20044387018
SN - 1346-9843
VL - 69
SP - 177
EP - 182
JO - Circulation Journal
JF - Circulation Journal
IS - 2
ER -