Assessing key clinical parameters before and after intraventricular hemorrhage in very preterm infants

Renée Lampe, Esther Rieger-Fackeldey, Irina Sidorenko, Varvara Turova, Nikolai Botkin, Laura Eckardt, Ana Alves-Pinto, Andrey Kovtanyuk, Michael Schündeln, Ursula Felderhoff-Müser

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Intraventricular cerebral hemorrhage (IVH) is one of the most severe complications of premature birth, potentially leading to lifelong disability. The purpose of this paper is the assessment of the evolution of three of the most relevant parameters, before and after IVH: mean arterial pressure (MAP), arterial carbon dioxide pressure (pCO2), and cerebral blood flow (CBF). Clinical records of 254 preterm infants with a gestational age of 23–30 weeks, with and without a diagnosis of IVH, were reviewed for MAP and arterial pCO2 in the period up to 7 days before and 3 days after IVH or during the first 10 days of life in cases without IVH. Conclusion: A statistically significant increase in pCO2 and decrease in MAP in patients with IVH compared with those without were detected. Both the mean values and the mean absolute deviations of CBF were computed in this study, and the latter was significantly higher than in control group. High deviations of CBF, as well as hypercapnia and hypotension, are likely to contribute to the rupture of cerebral blood vessels in preterm infants, and consequently, to the development of IVH.What is Known:• The origin of IVH is multifactorial, but mean arterial pressure, carbon dioxide partial pressure, and cerebral blood flow are recognized as the most important parameters.• In premature infants, the autoregulation mechanisms are still underdeveloped and cannot compensate for cerebral blood flow fluctuations.What is New:• The numerical simulation of CBF is shown to be a promising approach that may be useful in the care of preterm infants.• The mean values of CBF before and after IVH in the affected group were similar to those in the control group, but the mean absolute deviations of CBF in the affected group before and after IVH were significantly higher than that in the control group.

Original languageEnglish
Pages (from-to)929-937
Number of pages9
JournalEuropean Journal of Pediatrics
Issue number6
StatePublished - 1 Jun 2020
Externally publishedYes


  • Arterial carbon dioxide pressure
  • Cerebral blood flow
  • Immature brain
  • Intraventricular cerebral hemorrhage
  • Mean arterial pressure
  • Preterm infants


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