Abstract
Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.
Original language | English |
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Pages (from-to) | 596-604 |
Number of pages | 9 |
Journal | Nature Reviews Cancer |
Volume | 9 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2009 |