ASimulatoR: splice-aware RNA-Seq data simulation

Quirin Manz; Olga Tsoy; Amit Fenn; Jan Baumbach; Uwe Völker; Markus List; Tim Kacprowski

doi:10.1093/bioinformatics/btab142

ASimulatoR: splice-aware RNA-Seq data simulation

Quirin Manz, Olga Tsoy, Amit Fenn, Jan Baumbach, Uwe Völker, Markus List, Tim Kacprowski

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Summary: A plethora of tools exist for RNA-Seq data analysis with a focus on alternative splicing (AS). However, appropriate data for their comparative evaluation is missing. The R package ASimulatoR simulates gold standard RNA-Seq datasets with fine-grained control over the distribution of AS events, which allow for evaluating alternative splicing tools, e.g. to study the effect of sequencing depth on the performance of AS event detection.

Original language	English
Pages (from-to)	3008-3010
Number of pages	3
Journal	Bioinformatics
Volume	37
Issue number	18
DOIs	https://doi.org/10.1093/bioinformatics/btab142
State	Published - 15 Sep 2021

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10.1093/bioinformatics/btab142

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AU - Baumbach, Jan

AU - Völker, Uwe

AU - List, Markus

AU - Kacprowski, Tim

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ASimulatoR: splice-aware RNA-Seq data simulation

Abstract

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