Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription

Priyanka Sharma, Antonios Lioutas, Narcis Fernandez-Fuentes, Javier Quilez, José Carbonell-Caballero, Roni H.G. Wright, Chiara Di Vona, François Le Dily, Roland Schüller, Dirk Eick, Baldomero Oliva, Miguel Beato

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Sharma et al. discovered that arginine1810 at the C-terminal domain of RNAP2 is deiminated to citrulline (cit1810) by the peptidyl arginine deiminase 2. The cit1810 is required to facilitate RNAP2 association with P-TEFb complex and consequently allows the efficient transcription of the highly transcribed genes relevant for cellular proliferation.

Original languageEnglish
Pages (from-to)84-96.e7
JournalMolecular Cell
Volume73
Issue number1
DOIs
StatePublished - 3 Jan 2019
Externally publishedYes

Keywords

  • P-TEFb complex
  • PADI2
  • RNA polymerase II CTD
  • arginine1810
  • breast cancer cells
  • cell proliferation
  • citrullination
  • proximal promoter pausing

Fingerprint

Dive into the research topics of 'Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription'. Together they form a unique fingerprint.

Cite this