TY - JOUR
T1 - Are the associations of cardiac acceleration and deceleration capacities with fine metal particulate in welders mediated by inflammation
AU - Umukoro, Peter E.
AU - Wong, Jason Y.Y.
AU - Cavallari, Jennifer M.
AU - Fang, Shona C.
AU - Lu, Chensheng
AU - Lin, Xihong
AU - Mittleman, Murray A.
AU - Schmidt, Georg
AU - Christiani, David C.
N1 - Publisher Copyright:
© 2016 American College of Occupational and Environmental Medicine.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective: The aim of this study was to investigate whether associations of acceleration capacity (AC) and deceleration capacity (DC) with metal-PM 2.5 are mediated by inflammation. Methods: We obtained PM 2.5, C-reactive protein, interleukin (IL)-6, 8, and 10, and electrocardiograms to compute AC and DC, from 45 male welders. Mediation analyses were performed using linear mixed models to assess associations between PM 2.5 exposure, inflammatory mediator, and AC or DC, controlling for covariates. Results: The proportion of total effect of PM 2.5 on AC or DC (indirect effect) mediated through IL-6 on AC was 4% at most. Controlling for IL-6 (direct effect), a 1mg/m 3 increase of PM 2.5 was associated with a decrease of 2.16 (95% confidence interval -0.36 to 4.69) msec in AC and a decrease of 2.51 (95% confidence interval -0.90 to 5.93) msec in DC. Conclusion: IL-6 may be mediating the effect of metal particulates on AC.
AB - Objective: The aim of this study was to investigate whether associations of acceleration capacity (AC) and deceleration capacity (DC) with metal-PM 2.5 are mediated by inflammation. Methods: We obtained PM 2.5, C-reactive protein, interleukin (IL)-6, 8, and 10, and electrocardiograms to compute AC and DC, from 45 male welders. Mediation analyses were performed using linear mixed models to assess associations between PM 2.5 exposure, inflammatory mediator, and AC or DC, controlling for covariates. Results: The proportion of total effect of PM 2.5 on AC or DC (indirect effect) mediated through IL-6 on AC was 4% at most. Controlling for IL-6 (direct effect), a 1mg/m 3 increase of PM 2.5 was associated with a decrease of 2.16 (95% confidence interval -0.36 to 4.69) msec in AC and a decrease of 2.51 (95% confidence interval -0.90 to 5.93) msec in DC. Conclusion: IL-6 may be mediating the effect of metal particulates on AC.
UR - http://www.scopus.com/inward/record.url?scp=84963664754&partnerID=8YFLogxK
U2 - 10.1097/JOM.0000000000000674
DO - 10.1097/JOM.0000000000000674
M3 - Article
C2 - 26949872
AN - SCOPUS:84963664754
SN - 1076-2752
VL - 58
SP - 232
EP - 237
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 3
ER -
