Architecture of bacterial respiratory chains

Ville R.I. Kaila, Mårten Wikström

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations

Abstract

Bacteria power their energy metabolism using membrane-bound respiratory enzymes that capture chemical energy and transduce it by pumping protons or Na+ ions across their cell membranes. Recent breakthroughs in molecular bioenergetics have elucidated the architecture and function of many bacterial respiratory enzymes, although key mechanistic principles remain debated. In this Review, we present an overview of the structure, function and bioenergetic principles of modular bacterial respiratory chains and discuss their differences from the eukaryotic counterparts. We also discuss bacterial supercomplexes, which provide central energy transduction systems in several bacteria, including important pathogens, and which could open up possible avenues for treatment of disease.

Original languageEnglish
Pages (from-to)319-330
Number of pages12
JournalNature Reviews Microbiology
Volume19
Issue number5
DOIs
StatePublished - May 2021
Externally publishedYes

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